Differences of Microbiomes Found in Non-Inflammatory and Inflammatory Lesions of Acne Vulgaris

• Published in: Clinical, cosmetic and investigational dermatology Vol. 13; pp. 773 - 780
• Main Authors: Jusuf, Nelva Karmila, Putra, Imam Budi, Sari, Lovena
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2020; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Acne; acne vulgaris; Actors; Consent; Identification documents; Inflammation; inflammatory; microbiome; non-inflammatory; Original Research; Reagents; Staphylococcus aureus infections; Statistical analysis; Tumor necrosis factor-TNF; Indonesia; Jakarta Indonesia; acne vulgaris; non-inflammatory; microbiome; inflammatory
• ISSN: 1178-7015; 1178-7015
• DOI: 10.2147/CCID.S272334

Bacterial activity and inflammation both influence acne vulgaris (AV) formation. is considered as an actor involved in inflammation of AV. Besides , other microbiomes found in AV may also play a role in the pathogenesis. This research was conducted to overview microbiomes found in non-inflammatory and inflammatory lesions of AV. An observational descriptive study with cross-sectional approach was designed. Sample collection was performed with 40 subjects with AV. In every patient, both non-inflammatory (closed comedone) and inflammatory (pustule) lesion samples were collected by swab. Afterward, bacterial culture was performed, continued by bacterial identification. In non-inflammatory lesions, the growth of nine bacterial species was observed from 40 samples. In an anaerobic culture, (17,5%) was identified. In aerobic cultures, different bacterial species were found including (52.5%), (12.5%), (7.5%), (7.5%), (7.5%), (5%), (5%), and (2.5%). In inflammatory lesions, nine bacterial species were found, in which was the anaerobic culture we identified (25.0%). Aerobic cultures have revealed the growth colonies of (42.5%), (22.5%), (12.5%), (10.0%), (5.0%), (2.5%), (2.5%), and (2.5%). Two mixed bacterial growths were observed in non-inflammatory lesions, while four mixed bacterial growths were found in inflammatory lesions. Differences in bacterial isolates were observed both in non-inflammatory and inflammatory lesions of AV.