Gadolinium-doped hollow CeO2-ZrO2 nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicle

Developing multifunctional nanoparticle-based theranostic platform for cancer diagnosis and treatment is highly desirable, however, most of the present theranostic platforms are fabricated via complicated structure/composition design and time-consuming synthesis procedures. Herein, the multifunction...

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Published inDrug delivery Vol. 25; no. 1; pp. 353 - 363
Main Authors Wei, Zuwu, Wu, Ming, Li, Zuanfang, Lin, Zhan, Zeng, Jinhua, Sun, Haiyan, Liu, Xiaolong, Liu, Jingfeng, Li, Buhong, Zeng, Yongyi
Format Journal Article
LanguageEnglish
Published Philadelphia Taylor & Francis 25.01.2018
Taylor & Francis Ltd
Taylor & Francis Group
Subjects
Biomedical materials
Cancer therapies
Chemotherapy
Contrast agents
Drug delivery
Drug delivery systems
dual-modal imaging
Hospitals
Laboratories
Medicine
multifunctional
Nanoparticles
nanoplatform
Nanotechnology
NMR
Nuclear magnetic resonance
Photonics
theranostic
Tumors
Ultrasonic imaging
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Abstract Developing multifunctional nanoparticle-based theranostic platform for cancer diagnosis and treatment is highly desirable, however, most of the present theranostic platforms are fabricated via complicated structure/composition design and time-consuming synthesis procedures. Herein, the multifunctional Gd/CeO 2 -ZrO 2 /DOX-PEG nanoplatform with single nano-structure was fabricated through a facile route, which possessed MR/CT dual-model imaging and chemotherapy ability. The nanoplatform not only exhibited well-defined shapes, tunable compositions and narrow size distributions, but also presented a well anti-cancer effect and MR/CT imaging ability. Therefore, the Gd/CeO 2 -ZrO 2 /DOX-PEG nanoplatform could be applied for chemotherapy as well as dual-model MR/CT imaging.
AbstractList Developing multifunctional nanoparticle-based theranostic platform for cancer diagnosis and treatment is highly desirable, however, most of the present theranostic platforms are fabricated via complicated structure/composition design and time-consuming synthesis procedures. Herein, the multifunctional Gd/CeO2-ZrO2/DOX-PEG nanoplatform with single nano-structure was fabricated through a facile route, which possessed MR/CT dual-model imaging and chemotherapy ability. The nanoplatform not only exhibited well-defined shapes, tunable compositions and narrow size distributions, but also presented a well anti-cancer effect and MR/CT imaging ability. Therefore, the Gd/CeO2-ZrO2/DOX-PEG nanoplatform could be applied for chemotherapy as well as dual-model MR/CT imaging.
Developing multifunctional nanoparticle-based theranostic platform for cancer diagnosis and treatment is highly desirable, however, most of the present theranostic platforms are fabricated via complicated structure/composition design and time-consuming synthesis procedures. Herein, the multifunctional Gd/CeO 2 -ZrO 2 /DOX-PEG nanoplatform with single nano-structure was fabricated through a facile route, which possessed MR/CT dual-model imaging and chemotherapy ability. The nanoplatform not only exhibited well-defined shapes, tunable compositions and narrow size distributions, but also presented a well anti-cancer effect and MR/CT imaging ability. Therefore, the Gd/CeO 2 -ZrO 2 /DOX-PEG nanoplatform could be applied for chemotherapy as well as dual-model MR/CT imaging.
Author Wei, Zuwu
Li, Zuanfang
Liu, Xiaolong
Liu, Jingfeng
Zeng, Yongyi
Sun, Haiyan
Wu, Ming
Lin, Zhan
Zeng, Jinhua
Li, Buhong
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  organization: Liver Disease Center, the First Affiliated Hospital of Fujian Medical University
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SubjectTerms Biomedical materials
Cancer therapies
Chemotherapy
Contrast agents
Drug delivery
Drug delivery systems
dual-modal imaging
Hospitals
Laboratories
Medicine
multifunctional
Nanoparticles
nanoplatform
Nanotechnology
NMR
Nuclear magnetic resonance
Photonics
theranostic
Tumors
Ultrasonic imaging
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Title Gadolinium-doped hollow CeO2-ZrO2 nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicle
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