Gadolinium-doped hollow CeO2-ZrO2 nanoplatform as multifunctional MRI/CT dual-modal imaging agent and drug delivery vehicle

• Published in: Drug delivery Vol. 25; no. 1; pp. 353 - 363
• Main Authors: Wei, Zuwu, Wu, Ming, Li, Zuanfang, Lin, Zhan, Zeng, Jinhua, Sun, Haiyan, Liu, Xiaolong, Liu, Jingfeng, Li, Buhong, Zeng, Yongyi
• Format: Journal Article
• Language: English
• Published: Philadelphia Taylor & Francis 25.01.2018; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: Biomedical materials; Cancer therapies; Chemotherapy; Contrast agents; Drug delivery; Drug delivery systems; dual-modal imaging; Hospitals; Laboratories; Medicine; multifunctional; Nanoparticles; nanoplatform; Nanotechnology; NMR; Nuclear magnetic resonance; Photonics; theranostic; Tumors; Ultrasonic imaging
• ISSN: 1071-7544; 1521-0464
• DOI: 10.1080/10717544.2018.1428241

Developing multifunctional nanoparticle-based theranostic platform for cancer diagnosis and treatment is highly desirable, however, most of the present theranostic platforms are fabricated via complicated structure/composition design and time-consuming synthesis procedures. Herein, the multifunctional Gd/CeO 2 -ZrO 2 /DOX-PEG nanoplatform with single nano-structure was fabricated through a facile route, which possessed MR/CT dual-model imaging and chemotherapy ability. The nanoplatform not only exhibited well-defined shapes, tunable compositions and narrow size distributions, but also presented a well anti-cancer effect and MR/CT imaging ability. Therefore, the Gd/CeO 2 -ZrO 2 /DOX-PEG nanoplatform could be applied for chemotherapy as well as dual-model MR/CT imaging.