Subjective assessment of brexpiprazole in patients with schizophrenia: a prospective observational study
Objectives: To investigate the subjective assessments of an antipsychotic treatment with brexpiprazole.Methods: This was a 14-week prospective observational study. Nineteen patients participated in the study between February 2019 and January 2020.Results: Patients had a mean age of 40.6±14.2 years a...
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Published in | Fujita Medical Journal Vol. 9; no. 3; pp. 231 - 235 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Japan
Fujita Medical Society
2023
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Subjects | |
Online Access | Get full text |
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Summary: | Objectives: To investigate the subjective assessments of an antipsychotic treatment with brexpiprazole.Methods: This was a 14-week prospective observational study. Nineteen patients participated in the study between February 2019 and January 2020.Results: Patients had a mean age of 40.6±14.2 years and a Clinical Global Impressions-Severity of Illness scale (CGI-S) score of 4.6±1.2 at the initiation of brexpiprazole treatment. The Subjective Well-being under Neuroleptic drug treatment Short form, Japanese version (SWNS-J) total score significantly improved from 68.1±22.3 in week 2 to 79.5±21.0 in week 14 (p=0.0084). The SWNS-J subscales of self-control and social integration status also significantly improved from 14.0±4.7 and 13.9±6.0 in week 2 to 17.0±4.7 and 16.0±5.1 in week 14, respectively (p=0.0053 and 0.012, respectively). No significant improvements were observed in any other SWNS-J subscales or the Drug Attitude Inventory-10 (DAI-10) in the 14-week observation period. Moreover, the SWNS-J total score did not correlate with the DAI-10 (r=0.31, p=0.19), or CGI-S (r=–0.18, p=0.47) scores.Conclusions: The present results suggest that brexpiprazole might improve subjective well-being, although this may not necessarily reflect psychopathological improvements. To enhance medication adherence, it is important to perform subjective assessments on patients over time. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2189-7247 2189-7255 |
DOI: | 10.20407/fmj.2022-031 |