Association between oxidative balance score and kidney stones: data from the national health and nutrition examination survey (NHANES)

• Published in: BMC nephrology Vol. 25; no. 1; pp. 190 - 10
• Main Authors: Song, Rundong, Wu, Ke, Ma, Minghai, Wang, Lu, Jiang, Yunzhong, Li, Jianpeng, Fan, Jinhai
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.06.2024; BioMed Central; BMC
• Subjects: Adult; Aged; Alcohol; Analysis; Antioxidants; Antioxidants - metabolism; Body mass index; Calculi; Care and treatment; Comorbidity; Diabetes; Diagnosis; Diet; Disease; Exercise; Female; Health aspects; Health surveys; Hispanic Americans; Humans; Hypertension; Inflammation; Kidney Calculi - epidemiology; Kidney Calculi - etiology; Kidney Calculi - metabolism; Kidney stones; Kidneys; Life Style; Lifestyles; Male; Males; Marital status; Middle Aged; National health and nutrition examination survey; Nephrolithiasis; Neutrophils; Nutrients; Nutrition research; Nutrition Surveys; Oxidative balance score; Oxidative Stress; Physical activity; Polls & surveys; Population; Reactive oxygen species; Restricted cubic spline regression analysis; Retrospective Studies; Secondary schools; Sociodemographics; Statistical analysis; Surveys; Variables; Vitamins; Womens health; United States; United States > US; Reactive oxygen species; Oxidative balance score; National health and nutrition examination survey; Restricted cubic spline regression analysis; Kidney stones
• ISSN: 1471-2369; 1471-2369
• DOI: 10.1186/s12882-024-03607-w

Some studies have found that the pathological formation of kidney stones is closely related to injury and inflammatory response. Behaviors such as dietary composition, physical activity, obesity and smoking can all affect the body's oxidative stress levels. In order to evaluate the effects of various diets and lifestyles on the body's oxidative and antioxidant systems, an oxidative balance score was developed. To investigate whether the OBS is associated with the development of kidney stones. Data were taken from the National Health and Nutrition Examination Survey (NHANES) from 2007-2018, followed by retrospective observational studies. The association between kidney stones and OBS was analyzed using survey-weighted logistic regression by adjusting for demographics, laboratory tests, and medical comorbidity covariates. The oxidative balance score is calculated by screening 16 nutrients and 4 lifestyle factors, including 5 prooxidants and 15 antioxidants, based on prior information about the relationship between oxidation levels in the body and nutrients or lifestyle factors. A total of 26,786 adult participants were included in the study, of which 2,578, or 9.62%, had a history of nephrolithiasis. Weighted logistic regression analysis found an association between OBS and kidney stones. In the fully tuned model, i.e., model 3, the highest quartile array of OBS was associated with the lowest quartile array of OBS (OR = 0.73 (0.57, 0.92)) with the risk of kidney stone (p = 0.01), and was statistically significant and remained relatively stable in each model. At the same time, the trend test in the model is also statistically significant. With the increase of OBS, the OR value of kidney stones generally tends to decrease. There is an inverse correlation between OBS and kidney stone disease. At the same time, higher OBS suggests that antioxidant exposure is greater than pro-oxidative exposure in diet and lifestyle, and is associated with a lower risk of kidney stones.