Quercetin may reduce the risk of developing the symptoms of COVID-19
Recent evidence reported that some dietary compounds like quercetin and apigenin as the most well-known flavonoids with anti-inflammatory effects may inhibit SARS-CoV-2 main protease. The hypothesis of the promising effects and possible mechanisms of action of quercetin against COVID-19 were assesse...
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Published in | Avicenna journal of phytomedicine Vol. 14; no. 2; pp. 189 - 201 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Iran
Mashhad University of Medical Sciences
01.03.2024
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Subjects | |
Online Access | Get full text |
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Summary: | Recent evidence reported that some dietary compounds like quercetin and apigenin as the most well-known flavonoids with anti-inflammatory effects may inhibit SARS-CoV-2 main protease. The hypothesis of the promising effects and possible mechanisms of action of quercetin against COVID-19 were assessed in this article.
Related papers on the inhibitory effects of quercetin against COVID-19 were collected using the following search strategy: "corona or coronavirus or COVID or COVID-19 or viral or virus" AND "nutrient or flavonoid or Quercetin".
The findings indicated that quercetin can be considered an effective agent against COVID-19 because of its SARS-CoV-2 main protease and RNA-dependent RNA polymerase inhibitory effects. In addition, quercetin may attenuate angiotensin-converting enzyme-2 (ACE-2) receptors leading to a reduction of SARS-CoV-2 ability to enter host cells. Moreover, the antiviral, anti-inflammatory, and immunomodulatory activities of quercetin have been frequently reported.
Quercetin may be an effective agent for managing the complications of COVID-19. Further longitudinal human studies are warranted. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
ISSN: | 2228-7930 2228-7949 |
DOI: | 10.22038/AJP.2023.22920 |