Kidney Aging and Chronic Kidney Disease

• Published in: International journal of molecular sciences Vol. 25; no. 12; p. 6585
• Main Authors: Zhang, Yingying, Yu, Chen, Li, Xiaogang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.06.2024; MDPI
• Subjects: Age; Aging; Aging - pathology; Animals; Arteriosclerosis; Atherosclerosis; Atrophy; Autophagy; Cell cycle; cell senescence; Cellular Senescence; Chronic illnesses; chronic kidney disease; Chronic kidney failure; Cysts; Development and progression; Electrolytes; Epigenesis, Genetic; Epigenetic inheritance; Epigenetics; Health aspects; Health care; Hemodialysis; Humans; Hypertension; Hypoxia; Ischemia; Kidney - metabolism; Kidney - pathology; kidney aging; Kidney diseases; Mitochondria - genetics; Mitochondria - metabolism; Mitochondria - pathology; Older people; Population; Potassium; Renal Insufficiency, Chronic - etiology; Renal Insufficiency, Chronic - metabolism; Renal Insufficiency, Chronic - pathology; Review; Senescence; Toxins; Urine; Veins & arteries; kidney aging; chronic kidney disease; cell senescence
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25126585

The process of aging inevitably leads to an increase in age-related comorbidities, including chronic kidney disease (CKD). In many aspects, CKD can be considered a state of accelerated and premature aging. Aging kidney and CKD have numerous common characteristic features, ranging from pathological presentation and clinical manifestation to underlying mechanisms. The shared mechanisms underlying the process of kidney aging and the development of CKD include the increase in cellular senescence, the decrease in autophagy, mitochondrial dysfunction, and the alterations of epigenetic regulation, suggesting the existence of potential therapeutic targets that are applicable to both conditions. In this review, we provide a comprehensive overview of the common characteristics between aging kidney and CKD, encompassing morphological changes, functional alterations, and recent advancements in understanding the underlying mechanisms. Moreover, we discuss potential therapeutic strategies for targeting senescent cells in both the aging process and CKD.