Clinical features and histological patterns of lupus nephritis in eastern Nepal

To determine the clinical profile and patterns of lupus nephritis patients in Eastern Nepal, we studied 38 patients fulfilling the 1982 revised criteria of American College of Rheumatology for systemic lupus erythematous (SLE), followed up from January 2004 to January 2008. Arthritis was a common in...

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Published inSaudi journal of kidney diseases and transplantation Vol. 22; no. 2; pp. 377 - 380
Main Authors Rijal, Suman, Karkil, Prahlad, Dhakal, Subodh Sagar, Karki, Smriti, Bhattarai, Sabina, Bhatta, Narendra, Sharma, Sanjib Kumar, Shrestha, Shailendra
Format Journal Article
LanguageEnglish
Published Riyadh, Saudi Arabia Saudi Center for Organ Transplantation 01.03.2011
Medknow Publications and Media Pvt. Ltd
Wolters Kluwer Medknow Publications
Subjects
Adolescent
Adult
Antibodies, Antinuclear - blood
Biomarkers - blood
Biopsy
Care and treatment
Diagnosis
Disease Progression
Female
Humans
Kidney - pathology
Kidneys
Lupus nephritis
Lupus Nephritis - epidemiology
Lupus Nephritis - immunology
Lupus Nephritis - pathology
Middle Aged
Nepal - epidemiology
Nephritis
Rheumatoid Factor - blood
Risk factors
Severity of Illness Index
Time Factors
Young Adult
التشخيص
التغيرات النسيجية
التهاب الكلى الذئبي
المرضى
Nepal
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Summary:To determine the clinical profile and patterns of lupus nephritis patients in Eastern Nepal, we studied 38 patients fulfilling the 1982 revised criteria of American College of Rheumatology for systemic lupus erythematous (SLE), followed up from January 2004 to January 2008. Arthritis was a common initial feature in addition to variable cutaneous, cardiac, pulmonary and neuropsychiatric manifestations. Renal biopsy showed grade 1 changes in 5 (13.5 %) patients, grade 2 changes in 13 (35.1 %) patients, grade 3 changes in 9 (24.3 %) patients, grade 4 changes in 7 (18.9 %) patients, grade 5 changes in 2 (5.4 %) patients, and grade 6 changes in 2.7 % patients. Antinuclear antibody (ANA) assay and anti-ds DNA were positive in 78.4 and 81.1 %, respectively. We conclude that meningeal proliferative glomerulonephritis (grade 2) was the most common pattern of lupus nephritis encountered in our study. Timely diagnosis and treatment may improve the overall patients’ survival.
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ISSN:1319-2442
2320-3838