Talaroacids A-D and Talaromarane A, Diterpenoids with Anti-Inflammatory Activities from Mangrove Endophytic Fungus Talaromyces sp. JNQQJ-4

• Published in: International journal of molecular sciences Vol. 25; no. 12; p. 6691
• Main Authors: Wang, Guisheng, Wu, Jianying, Li, Zhaokun, Chen, Tao, Liu, Yufeng, Wang, Bo, Chen, Yan, She, Zhigang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.06.2024; MDPI
• Subjects: Animals; anti-inflammatory; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - isolation & purification; Anti-Inflammatory Agents - pharmacology; Anti-inflammatory drugs; Carbon; Diterpenes - chemistry; Diterpenes - isolation & purification; Diterpenes - pharmacology; diterpenoids; Fungi; Hydrogenation; Magnetic Resonance Spectroscopy; mangrove endophytic fungus; Mice; Molecular Structure; RAW 264.7 Cells; Talaromyces - chemistry; Talaromyces sp; Japan; China; anti-inflammatory; diterpenoids; Talaromyces sp; mangrove endophytic fungus
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25126691

Five new diterpenes including four diterpenes with 1,2,3,4,4a,5,6,8a-octalin skeleton talaroacids A-D ( - ) and an isopimarane diterpenoid talaromarane A ( ) were isolated from the mangrove endophytic fungus sp. JNQQJ-4. Their structures and absolute configurations were determined by analysis of high-resolution electrospray ionization mass spectroscopy (HRESIMS), 1D/2D Nuclear Magnetic Resonance (NMR) spectra, single-crystal X-ray diffraction, quantum chemical calculation, and electronic circular dichroism (ECD). Talaromarane A ( ) contains a rare 2-oxabicyclo [3.2.1] octan moiety in isopimarane diterpenoids. In bioassays, compounds , , , and displayed significant anti-inflammatory activities with the IC value from 4.59 to 21.60 μM.