Extracellular Vesicles in Diabetic Cardiomyopathy-State of the Art and Future Perspectives

Cardiovascular complications are the most deadly and cost-driving effects of diabetes mellitus (DM). One of them, which is steadily attracting attention among scientists, is diabetes-induced heart failure, also known as diabetic cardiomyopathy (DCM). Despite significant progress in the research conc...

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Published inInternational journal of molecular sciences Vol. 25; no. 11; p. 6117
Main Authors Zygmunciak, Przemysław, Stróżna, Katarzyna, Błażowska, Olga, Mrozikiewicz-Rakowska, Beata
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.06.2024
MDPI
Subjects
Animals
B cells
Cardiomyocytes
Cardiomyopathy
Cardiovascular disease
DCM
Diabetes
Diabetic Cardiomyopathies - metabolism
Diabetic Cardiomyopathies - pathology
diabetic cardiomyopathy
Diabetics
Ejection fraction
Endothelium
exosomes
Extracellular vesicles
Extracellular Vesicles - metabolism
Fatty acids
Gene expression
Genotype & phenotype
Glucose
Heart diseases
Heart failure
Humans
Hyperglycemia
Hypertension
Insulin
Medical research
Medicine, Experimental
Metabolism
micro-RNA
Oxidation
Pathogenesis
Population
Review
Type 2 diabetes
heart failure
extracellular vesicles
exosomes
diabetic cardiomyopathy
diabetes
micro-RNA
DCM
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Summary:Cardiovascular complications are the most deadly and cost-driving effects of diabetes mellitus (DM). One of them, which is steadily attracting attention among scientists, is diabetes-induced heart failure, also known as diabetic cardiomyopathy (DCM). Despite significant progress in the research concerning the disease, a universally accepted definition is still lacking. The pathophysiology of the processes accelerating heart insufficiency in diabetic patients on molecular and cellular levels also remains elusive. However, the recent interest concerning extracellular vesicles (EVs) has brought promise to further clarifying the pathological events that lead to DCM. In this review, we sum up recent investigations on the involvement of EVs in DCM and show their therapeutic and indicatory potential.
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These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25116117