Anti-Obesity Properties of Blackberries Fermented with L. plantarum JBMI F5 via Suppression of Adipogenesis Signaling Mechanisms

• Published in: International journal of molecular sciences Vol. 25; no. 11; p. 6164
• Main Authors: Park, Jae Young, Kim, Ha-Rim, Lee, Seung-Hyeon, Lee, Sang-Wang, Sin, Hong-Sig, Lim, Tae-Gyu, Kim, Seon-Young, Park, Mi Hee
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.06.2024; MDPI
• Subjects: Adipocytes; adipogenesis; Adipogenesis - drug effects; Animals; Anti-Obesity Agents - pharmacology; Berries; Blackberries; Blood pressure; Body fat; Body weight; Body Weight - drug effects; Cancer; CCAAT-Enhancer-Binding Proteins - genetics; CCAAT-Enhancer-Binding Proteins - metabolism; Diabetes; Diet, High-Fat - adverse effects; Disease; Fermentation; high fat diet; Insulin resistance; L. plantarum JBMI F5; Lactobacillus plantarum; Leptin; Leptin - blood; Leptin - metabolism; Lipids; Liraglutide; Liver; Male; Metabolic disorders; Metabolites; Mice; Mice, Inbred C57BL; Microorganisms; Obesity; Obesity - metabolism; Oxidative stress; Plant Extracts - chemistry; Plant Extracts - pharmacology; Polyphenols; PPAR gamma - metabolism; Proteins; Raw materials; Rubus - chemistry; Signal Transduction - drug effects; Sterol Regulatory Element Binding Protein 1 - genetics; Sterol Regulatory Element Binding Protein 1 - metabolism; Toxicity; Triglycerides; Triglycerides - blood; Triglycerides - metabolism; Type 2 diabetes; Weight control; South Korea; blackberries; L. plantarum JBMI F5; adipogenesis; high fat diet; obesity
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25116164

Blackberries ( ), which are known to include a variety of bioactive substances, have been extensively studied for their antioxidant properties. Blackberries possess multiple health beneficial effects, including anti-inflammation, anti-atherosclerosis, anti-tumor and immunomodulatory activity. However, the potential biological effects and precise molecular mechanisms of the fermented extracts remain largely unexplored. In this research, we demonstrate the effect of blackberries fermented with for addressing obesity. We investigated the effect of blackberries fermented by on mice fed a high-fat (60% kcal) diet for 12 weeks. Fermented blackberry administration reduced the body weight and epididymal fat caused by a high-fat diet compared to the obese group. The triglyceride and total cholesterol, which are blood lipid indicators, and the levels of leptin, which is an insulin resistance indicator, were significantly increased in the obese group but were significantly decreased in the fermented blackberries-treated group. Additionally, the expression of adipogenesis marker proteins, such as CEBPα, PPAR-γ and SREBP-1, was significantly increased in the obese group, whereas it was decreased in the fermented blackberries-treated group. These results suggest that fermented blackberries have a protective effect against high-fat-diet-induced obesity by inhibiting adipogenesis and are a potential candidate for the treatment of obesity.