A case of severe carbamazepine overdose treated successfully with combined hemoperfusion and hemodialysis technique

Carbamazepine intoxication manifests as altered mental status ranging from drowsiness to a coma and/or cardiac abnormalities such as sinus tachycardia, prolongation of the QRS interval, ventricular tachycardia, and hypotension. The patient may be agitated, but central nervous system (CNS) depression...

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Published inSaudi journal of kidney diseases and transplantation Vol. 28; no. 4; pp. 906 - 908
Main Authors Vallianou, Natalia, Giannopoulou, Myrto, Trigkidis, Kyriakos, Bei, Elefteria, Margellou, Evangelia, Apostolou, Theofanis
Format Journal Article
LanguageEnglish
Published Riyadh, Saudi Arabia Saudi Center for Organ Transplantation 01.07.2017
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Wolters Kluwer Medknow Publications
Subjects
Antidepressants
Carbamazepine
Cardiac arrest
Care and treatment
Central nervous system
Charcoal
Dosage and administration
Drug dosages
Drug overdose
Epilepsy
Hemodialysis
Internal medicine
Management
Nephrology
Oxcarbazepine
Poisoning
Toxicity
الجرعات الزائدة
الدم
غسيل الكلى
كاربامازيبين
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Summary:Carbamazepine intoxication manifests as altered mental status ranging from drowsiness to a coma and/or cardiac abnormalities such as sinus tachycardia, prolongation of the QRS interval, ventricular tachycardia, and hypotension. The patient may be agitated, but central nervous system (CNS) depression and presentation with coma is more common and could be lethal. Serious CNS toxicity often requires hemoperfusion and/or hemodialysis (HD). Herein, we present a case of a comatose patient, who was treated with a combination of hemoperfusion and HD in series. Our approach to treat the patient with a combination of hemoperfusion and HD was based on evidence from the literature supporting that the hemoperfusion and HD in series might provide the best clearance of carbamazepine
ISSN:1319-2442
2320-3838