Antigenic Variation of Avian Influenza A(H5N6) Viruses, Guangdong Province, China, 2014-2018

• Published in: Emerging infectious diseases Vol. 25; no. 10; pp. 1932 - 1935
• Main Authors: Bai, Ru, Sikkema, Reina S, Li, Cong Rong, Munnink, Bas B Oude, Wu, Jie, Zou, Lirong, Jing, Yi, Lu, Jing, Yuan, Runyu, Liao, Ming, Koopmans, Marion P G, Ke, Chang-Wen
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.10.2019; Centers for Disease Control and Prevention
• Subjects: Animals; Antibodies; Antigenic variation; Antigens, Viral - genetics; Antigens, Viral - immunology; Avian influenza; Chickens - virology; China; China - epidemiology; Ducks; Geese; Genetic Drift; Guangdong Province; H5N6; Health aspects; Infection; Influenza; Influenza A virus - genetics; Influenza A virus - immunology; Influenza in Birds - epidemiology; Influenza in Birds - genetics; Influenza in Birds - immunology; Influenza in Birds - virology; Influenza vaccines; Phylogeny; Poultry Diseases - epidemiology; Poultry Diseases - immunology; Poultry Diseases - virology; Real-Time Polymerase Chain Reaction - veterinary; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction - veterinary; Vaccination; zoonosis; China; chickens; poultry; viruses; avian influenza; Guangdong Province; H5N6; live poultry markets; Antigenic variation; China; zoonoses
• ISSN: 1080-6040; 1080-6059; 1080-6059
• DOI: 10.3201/eid2510.190274

Market surveillance showed continuing circulation of avian influenza A(H5N6) virus in live poultry markets in Guangdong Province in 2017, despite compulsory vaccination for avian influenza A(H5Nx) and A(H7N9). We analyzed H5N6 viruses from 2014-2018 from Guangdong Province, revealing antigenic drift and decreased antibody response against the vaccine strain in vaccinated chickens.