Prevalence and factors associated with transfusion-transmissible infections (HIV, HBV, HCV and Syphilis) among blood donors in Gabon: Systematic review and meta-analysis

• Published in: PloS one Vol. 19; no. 8; p. e0307101
• Main Authors: Mangala, Christian, Maulot-Bangola, Denis, Moutsinga, Alain, Okolongo-Mayani, Serge Christian, Matsomo-Kombet, Gwladys Esmeralda, Moundanga, Mireille, Mombo-Maganga, Christian, Mabika-Obanda, Alfred Keith Felix, Fokam, Joseph
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.08.2024; Public Library of Science (PLoS)
• Subjects: Analysis; Biology and Life Sciences; Blood; Blood & organ donations; Blood banks; Blood donors; Blood Donors - statistics & numerical data; Blood Transfusion; Blood transfusions; Content analysis; Female; Gabon - epidemiology; Health aspects; Hepatitis B; Hepatitis B - epidemiology; Hepatitis C; Hepatitis C - epidemiology; Hepatitis C - transmission; Hepatitis C virus; Heterogeneity; HIV; HIV (Viruses); HIV infection; HIV Infections - epidemiology; Human immunodeficiency virus; Humans; Industrialized nations; Infection; Infections; Male; Medicine and Health Sciences; Meta-analysis; Pathogens; Physical Sciences; Prevalence; Public health; Research and Analysis Methods; Reviews; Risk Factors; Serology; Sexually transmitted diseases; Sociodemographics; Software; Statistical analysis; STD; Surveillance; Syphilis; Syphilis - epidemiology; Systematic review; Transfusion; Transfusion Reaction - epidemiology; Viruses; Visual effects; Gabon; Iran; Sub-Saharan Africa; Ethiopia
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0307101

Transfusion-transmissible infections (TTIs) remain a major public health problem in countries with limited resources, particularly in Gabon. Complete information on the prevalence in Gabon of the main TTIs among blood donors is still lacking in the national context. The purpose of this systematic review and meta-analysis was to determine the prevalence and factors associated with TTIs among blood donors in Gabon. This systematic review and meta-analysis was reported in accordance with the PRISMA 2020 guidelines. It was the result of data from several comprehensive studies published between 2014 and 2022, the purpose of which focused on the prevalence and factors associated with TTIs among blood donors in Gabon. The quality of the articles was assessed using the Joanna Briggs Institute critical appraisal checklist for studies reporting prevalence data. The overall prevalence of TTIs among blood donors was determined using the random effects model. Heterogeneity between studies was assessed using I2 statistics. Publication bias was assessed by visual inspection of the funnel plot and Egger's statistics. A total of 175,140 blood donors from the nine eligible studies were admitted to this study. The combined prevalence of HIV, HBV, HCV and syphilis obtained in the random effects model was 3.0%, 6.0%, 4.0% and 3.0%, respectively. Moreover, being a male blood donor and aged between 25 and 44 years was significantly associated with HBV infection and being a female blood donor and aged 35 years and over was significantly associated with HIV infection. Family or replacement blood donors had a high infection burden for all four TTIs of study. The overall prevalence of transfusion-transmissible infections remains high in the country's blood banks. Improving current prevention (selection criteria) and screening strategies may be necessary in a global approach.