Synergistic Therapeutic Effects of D-Mannitol–Cerium–Quercetin Coordination Polymer Nanoparticles on Acute Lung Injury

• Published in: Molecules (Basel, Switzerland) Vol. 29; no. 12; p. 2819
• Main Authors: Zhang, Yusheng, Wang, Hong, Yang, Ruiying, Zhang, Ying, Chen, Yao, Jiang, Cuiping, Li, Xianyu
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.06.2024; MDPI
• Subjects: acute lung injury; Analysis; Antioxidants; Biocompatibility; Cerium; cerium ions; Cerium oxides; D-mannitol; Drug delivery systems; Drugs; Ethylenediaminetetraacetic acid; Fourier transforms; Health aspects; Homeopathy; Inflammation; Injuries; Ligands; Lung diseases; Mannitol; Mass spectrometry; Materia medica and therapeutics; Morphology; Nanoparticles; Oxidative stress; Particle size; Pharmacokinetics; Polymer industry; Polymers; Polyphenols; quercetin; rutin; Scientific imaging; self-assembly; Therapeutics; Transmission electron microscopy; Ventilation; Ventilators; China
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules29122819

Acute lung injury (ALI) remains a significant global health issue, necessitating novel therapeutic interventions. In our latest study, we pioneered the use of D-mannitol–cerium–quercetin/rutin coordination polymer nanoparticles (MCQ/R NPs) as a potential treatment for ALI. The MCQ/R NPs, which integrate rutin and quercetin for their therapeutic potential and D-mannitol for its pulmonary targeting, displayed exceptional efficacy. By utilizing cerium ions for optimal nanoparticle assembly, the MCQ/R NPs demonstrated an average size of less than 160 nm. Impressively, these nanoparticles outperformed conventional treatments in both antioxidative capabilities and biocompatibility. Moreover, our in vivo studies on LPS-induced ALI mice showed a significant reduction in lung tissue inflammation. This groundbreaking research presents MCQ/R NPs as a promising new approach in ALI therapeutics.