Incidence of hepatitis C infection in patients on hemodialysis: a multicenter study of northern part of Iran

Hepatitis C virus (HCV) is one of the perilous problems in hemodialysis (HD) centers around the world. There are many risk factors regarding HCV infection in HD units. The aim of this study was to evaluate the incidence of HCV infection in HD units and also to assess the potential risk factors in th...

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Published inSaudi journal of kidney diseases and transplantation Vol. 21; no. 6; pp. 1169 - 1171
Main Authors Zamani, Farhad, Ameli, Mitra, Razmjou, Sara, Shakeri, Ramin, Amiri, Afsaneh, Darvish, Rasoul
Format Journal Article
LanguageEnglish
Published Saudi Arabia Medknow Publications and Media Pvt. Ltd 01.11.2010
Wolters Kluwer Medknow Publications
Subjects
Adult
Aged
Biomarkers - blood
Care and treatment
Chi-Square Distribution
Chronic kidney failure
Complications and side effects
Disease transmission
Enzyme-Linked Immunosorbent Assay
Hemodialysis
Hepacivirus - genetics
Hepacivirus - immunology
Hepatitis C - diagnosis
Hepatitis C - epidemiology
Hepatitis C Antibodies - blood
Hepatitis C virus
Humans
Incidence
Iran
Middle Aged
Patient outcomes
Polymerase Chain Reaction
Prevention
Renal Dialysis
Risk Assessment
Risk Factors
RNA, Viral - blood
Sex Factors
Time Factors
Transfusion Reaction
Iran
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Summary:Hepatitis C virus (HCV) is one of the perilous problems in hemodialysis (HD) centers around the world. There are many risk factors regarding HCV infection in HD units. The aim of this study was to evaluate the incidence of HCV infection in HD units and also to assess the potential risk factors in this regard. A total of 334 patients on regular HD were evaluated. All the patients were seronegative for anti-HCV antibody in the beginning of this study. They were followed every 6 months with repetition of tests. Positive samples were tested by polymerase chain reaction (PCR) for confirmation. The prevalence of HCV infection was about 20%. No significant relationship between numbers of blood transfusion, age and sex was obtained. A positive correlation between HCV infection and duration of HD for more than 5 years was significant. In conclusion, our study found the prevalence of HCV infection to be significantly higher than its incidence in the general population.
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ISSN:1319-2442