Design, Synthesis and Bioactivities of Novel Pyridyl Containing Pyrazole Oxime Ether Derivatives

• Published in: Molecules (Basel, Switzerland) Vol. 29; no. 12; p. 2767
• Main Authors: He, Jie, Zhou, Beibei, Wang, Xinjuan, Chen, Qi, Jiang, Xiaoqian, Kong, Ting, Yao, Long, Zhao, Yingying, Chen, Rong, Xu, Ying, Dai, Hong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.06.2024; MDPI
• Subjects: Animals; biological activity; Drug Design; Drug dosages; Ethers - chemistry; Insecticides - chemical synthesis; Insecticides - chemistry; Insecticides - pharmacology; Molecular Structure; Moths - drug effects; Oximes - chemical synthesis; Oximes - chemistry; Oximes - pharmacology; Pesticides; Potash; Potassium; pyrazole oxime ether; Pyrazoles - chemical synthesis; Pyrazoles - chemistry; Pyrazoles - pharmacology; Pyridine; Pyridines - chemical synthesis; Pyridines - chemistry; Pyridines - pharmacology; Structure-Activity Relationship; synthesis; Beijing China; United States > US; China; synthesis; pyridine; pyrazole oxime ether; biological activity
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules29122767

In this research, with an aim to develop novel pyrazole oxime ether derivatives possessing potential biological activity, thirty-two pyrazole oxime ethers, including a substituted pyridine ring, have been synthesized and structurally identified through H NMR, C NMR, and HRMS. Bioassay data indicated that most of these compounds owned strong insecticidal properties against , , , and at a dosage of 500 μg/mL, and some title compounds were active towards at 500 μg/mL. Furthermore, some of the designed compounds had potent insecticidal effects against , , or at 100 μg/mL, with the mortalities of compounds , , , , , , , , , , and against , in particular, all reaching 100%. Even when the dosage was lowered to 20 μg/mL, compound also expressed 50% insecticidal activity against , and compounds , , , , , and displayed more than 60% inhibition rates against . The current results provided a significant basis for the rational design of biologically active pyrazole oxime ethers in future.