Candida spp. with acquired echinocandin resistance, France, 2004-2010

• Published in: Emerging infectious diseases Vol. 18; no. 1; pp. 86 - 90
• Main Authors: Dannaoui, Eric, Desnos-Ollivier, Marie, Garcia-Hermoso, Dea, Grenouillet, Fredéric, Cassaing, Sophie, Baixench, Marie-Thérèse, Bretagne, Stéphane, Dromer, Françoise, Lortholary, Olivier
• Format: Journal Article
• Language: English
• Published: United States Centers for Disease Control and Prevention 01.01.2012
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Antifungal Agents - pharmacology; Candida; Candida - classification; Candida - drug effects; Candida albicans; Candida glabrata; Candida krusei; Candidiasis; Candidiasis - epidemiology; Candidiasis - microbiology; caspofungin; Dispatch; Drug Resistance, Fungal; Echinocandins; Echinocandins - pharmacology; Female; FKS mutation; France; France - epidemiology; Humans; Life Sciences; Male; Microbial Sensitivity Tests; Microbiology and Parasitology; Middle Aged; Mycology; Young Adult; France

We report 20 episodes of infection caused by acquired echinocandin-resistant Candida spp. harboring diverse and new Fksp mutations. For 12 patients, initial isolates (low MIC, wild-type Fksp sequence) and subsequent isolates (after caspofungin treatment, high MIC, mutated Fksp) were genetically rela...