Candida spp. with acquired echinocandin resistance, France, 2004-2010

We report 20 episodes of infection caused by acquired echinocandin-resistant Candida spp. harboring diverse and new Fksp mutations. For 12 patients, initial isolates (low MIC, wild-type Fksp sequence) and subsequent isolates (after caspofungin treatment, high MIC, mutated Fksp) were genetically rela...

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Bibliographic Details
Published inEmerging infectious diseases Vol. 18; no. 1; pp. 86 - 90
Main Authors Dannaoui, Eric, Desnos-Ollivier, Marie, Garcia-Hermoso, Dea, Grenouillet, Fredéric, Cassaing, Sophie, Baixench, Marie-Thérèse, Bretagne, Stéphane, Dromer, Françoise, Lortholary, Olivier
Format Journal Article
LanguageEnglish
Published United States Centers for Disease Control and Prevention 01.01.2012
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
Antifungal Agents
Antifungal Agents - pharmacology
Candida
Candida - classification
Candida - drug effects
Candida albicans
Candida glabrata
Candida krusei
Candidiasis
Candidiasis - epidemiology
Candidiasis - microbiology
caspofungin
Dispatch
Drug Resistance, Fungal
Echinocandins
Echinocandins - pharmacology
Female
FKS mutation
France
France - epidemiology
Humans
Life Sciences
Male
Microbial Sensitivity Tests
Microbiology and Parasitology
Middle Aged
Mycology
Young Adult
France
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Summary:We report 20 episodes of infection caused by acquired echinocandin-resistant Candida spp. harboring diverse and new Fksp mutations. For 12 patients, initial isolates (low MIC, wild-type Fksp sequence) and subsequent isolates (after caspofungin treatment, high MIC, mutated Fksp) were genetically related.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMCID: PMC3310099
ISSN:1080-6059
1080-6040
1080-6059
DOI:10.3201/eid1801.110556