Prevalence of Drug-resistant Klebsiella pneumoniae in Iran: A Review Article

• Published in: Iranian journal of public health Vol. 47; no. 3; pp. 317 - 326
• Main Authors: Heidary, Mohsen, Nasiri, Mohammad Javad, Dabiri, Hossein, Tarashi, Samira
• Format: Journal Article
• Language: English
• Published: Iran Tehran University of Medical Sciences 01.03.2018
• Subjects: Active control; Ampicillin; Antibiotics; Antiinfectives and antibacterials; Aztreonam; Ceftazidime; Condition monitoring; Data processing; Drug resistance; Hygiene; Imipenem; Infections; Iran; Klebsiella; Klebsiella pneumoniae; Medical personnel; Nitrofurantoin; Physicians; Review; Iran; Iran; Drug resistance; Klebsiella pneumoniae
• ISSN: 2251-6085; 2251-6093

The infections caused by drug resistant strains of are becoming an important health problem worldwide. There are several reports on antimicrobial resistant status of in Iran. However, a comprehensive analysis on drug-resistant from different parts of Iran has not yet been performed. The searches were done according to several English and Persian databases including PubMed, Scopus, Iranmedex, and SID to identify studies addressing antibiotic resistant in Iran from Jan 1998 to Nov 2014. Comprehensive Meta-Analysis (V2.2, Biostat) software was used to analyze the data. The incidence rate of imipenem and ceftazidime resistance in isolates was 3.2% (95% confidence interval [CI], 1.5-6.5) and 55.7% (95% CI, 46.9-64.1), respectively. The highest rate of resistance in isolates of was seen against ampicillin (82.2%), aztreonam (55.4%) and nitrofurantoin (54.5%). There is a relatively high prevalence of drug resistant isolates in Iran. Thus, a high degree of awareness among physicians and microbiologists, active infection control committee, appropriate antimicrobial therapy, improvement of hygiene condition and monitoring of drug resistant isolates are urgently needed in order to better control the emergence and spread of drug-resistant isolates in hospital settings.