REVIEW: Current understanding of the pathogenesis of Fuchs' endothelial corneal dystrophy

Fuchs' endothelial corneal dystrophy (FECD) is the most prominent reason for corneal-endothelial transplantations across the globe. The disease pathophysiology manifests through a combination of various genetic and non-heritable factors. This review provides a comprehensive list of known geneti...

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Bibliographic Details
Published inMolecular vision Vol. 25; pp. 295 - 310
Main Authors Nanda, Gargi Gouranga, Alone, Debasmita Pankaj
Format Journal Article
LanguageEnglish
Published United States Molecular Vision 2019
Subjects
Acuity
Apoptosis
Cornea
Corneal dystrophy
Dystrophy
Extracellular matrix
Fuchs' Endothelial Dystrophy - epidemiology
Fuchs' Endothelial Dystrophy - genetics
Fuchs' Endothelial Dystrophy - pathology
Fuchs' Endothelial Dystrophy - therapy
fuchs’ endothelial corneal dystrophy
Genetic Predisposition to Disease
Humans
Oxidative Stress
Pathophysiology
Prevalence
Review
Reviews
Ribonucleic acid
Risk Factors
RNA
Toxicity
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Summary:Fuchs' endothelial corneal dystrophy (FECD) is the most prominent reason for corneal-endothelial transplantations across the globe. The disease pathophysiology manifests through a combination of various genetic and non-heritable factors. This review provides a comprehensive list of known genetic players that cause FECD, and discusses the prominent pathological features that participate in disease progression, such as channel dysfunction, abnormal extracellular matrix deposition, RNA toxicity, oxidative stress, and apoptosis. Although current practices to correct visual acuity involve surgical intervention, this review also discusses the scope of various non-surgical therapeutics to remedy FECD.
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SourceType-Scholarly Journals-1
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ISSN:1090-0535
1090-0535