Successful Management of Cervical and Tubal Stump Double Pregnancy after Assisted Reproductive Technologies Using Multiple High Doses of Methotrexate: A Case Report

• Published in: Iranian journal of medical sciences Vol. 49; no. 7; pp. 461 - 466
• Main Authors: Gaiday, Andrey, Tussupkaliyev, Akylbek, Nurken, Abay, Gaiday, Assel, Primbetova, Ainur, Dossimbetova, Moldir, Yeszhanova, Assemgul, Karimsakova, Bibigul, Ablakimova, Nurgul
• Format: Journal Article
• Language: English
• Published: Iran Shiraz University of Medical Sciences 01.07.2024
• Subjects: Abortifacient Agents, Nonsteroidal - administration & dosage; Abortifacient Agents, Nonsteroidal - therapeutic use; Adult; Case Report; Chorionic gonadotropin; Female; Fertility; Glycoproteins; Humans; Methotrexate; Methotrexate - administration & dosage; Methotrexate - adverse effects; Methotrexate - therapeutic use; Pregnancy; Pregnancy complications; pregnancy, ectopic; Pregnancy, Ectopic - drug therapy; Pregnant women; Reproductive Techniques, Assisted; Reproductive technologies; Reproductive technology; Ultrasonic imaging; Ultrasound imaging; Kazakhstan; Methotrexate; Reproductive techniques, assisted; Pregnancy, ectopic
• ISSN: 0253-0716; 1735-3688; 1735-3688
• DOI: 10.30476/IJMS.2024.102119.3487

The incidence of ectopic pregnancy (EP) has increased in recent years, owing to causes such as pelvic inflammatory diseases and assisted reproductive technologies (ART). The present study reported a case of a 33-year-old nulliparous woman with a history of previous ectopic pregnancies, who underwent pelvic ultrasound in August 2022, which revealed a double EP including a cervical pregnancy and a tubal stump pregnancy. Despite known risk factors and elevated beta-human chorionic gonadotropin (β-hCG) levels, a conservative approach, utilizing multiple doses of systemic methotrexate (MTX) injections, was employed to preserve fertility at the Regional Perinatal Center in Aktobe, Kazakhstan. Treatment efficacy was monitored through β-hCG levels and ultrasound imaging, with successful resolution of both EPs and preservation of reproductive function. The present case highlighted the safety and efficacy of MTX therapy in managing complex EP presentations, emphasizing the necessity of individualized treatment approaches in reproductive medicine, particularly in terms of preserving fertility in patients undergoing ART. Multiple high doses of MTX injections were beneficial for pregnancy with two distinct regions, fetal cardiac activity, and elevated serum β-hCG level. Further research is required to explore optimal treatment strategies for EP, considering patient-specific factors and treatment goals.