Facile construction of spiroindoline derivatives as potential anti-viral agent via three-component reaction in aqueous with β-cyclodextrin-SO3H as an efficient catalyst

A convenient and efficient β-cyclodextrin-SO 3 H-assisted strategy for construction of spiro indoline derivatives in aqueous media was disclosed. The present protocol showed various advantages including short reaction time, broad scope of substituents, simplicity of practice, high yields of products...

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Published inGreen chemistry letters and reviews Vol. 15; no. 1; pp. 139 - 152
Main Authors Xu, Fangzhou, Wang, Yanyan, He, Feng, Li, Zelian, Guo, Shengxin, Xie, Yun, Luo, Dexia, Wu, Jian
Format Journal Article
LanguageEnglish
Published Abingdon Taylor & Francis 02.01.2022
Taylor & Francis Ltd
Taylor & Francis Group
Subjects
Agricultural production
anti-viral activity
Antiviral agents
Antiviral drugs
aqueous
Aqueous solutions
Bioengineering
Catalysts
Cyclodextrin
Cyclodextrins
Green chemistry
Laboratories
Plant protection
Product safety
Protocol
Reaction time
Recyclability
Solvents
Spiroindoline derivatives
three-component reaction
Tobacco
β-Cyclodextrin-SO
β-cyclodextrin-so3h
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Summary:A convenient and efficient β-cyclodextrin-SO 3 H-assisted strategy for construction of spiro indoline derivatives in aqueous media was disclosed. The present protocol showed various advantages including short reaction time, broad scope of substituents, simplicity of practice, high yields of products, recyclability of catalysts, safety, and cheapness of benign solvents. Preliminary study indicated that some of spiroindoline derivatives exhibited anti-Tobacco Mosaic Virus (TMV) activity for potential use in plant protection.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:1751-8253
1751-7192
DOI:10.1080/17518253.2021.2023660