Synthesis of bioactive heterocycles using reusable heterogeneous catalyst HClO4-SiO2 under solvent-free conditions

We are reporting a simple, efficient and green protocol for the synthesis of chromenes and dihydropyrimidines (products of Knoevenagel and Biginelli reaction, respectively) by the use of silica-supported perchloric acid (HClO 4 -SiO 2 ) as an effective heterogeneous catalyst. Short reaction times, h...

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Bibliographic Details
Published inGreen chemistry letters and reviews Vol. 11; no. 3; pp. 352 - 360
Main Authors Chanu, Leimajam Vartima, Singh, Thokchom Prasanta, Devi, Laishram Ronibala, Singh, Okram Mukherjee
Format Journal Article
LanguageEnglish
Published Abingdon Taylor & Francis 03.07.2018
Taylor & Francis Ltd
Taylor & Francis Group
Subjects
Biginelli reaction
Catalysts
chromenes
dihydropyrimidine
green catalyst
Knoevenagel condensation
Perchloric acid
Silica
Silicon dioxide
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Summary:We are reporting a simple, efficient and green protocol for the synthesis of chromenes and dihydropyrimidines (products of Knoevenagel and Biginelli reaction, respectively) by the use of silica-supported perchloric acid (HClO 4 -SiO 2 ) as an effective heterogeneous catalyst. Short reaction times, high product yields, simple procedure and reusability of the catalyst are the superior characteristics of this protocol.
ISSN:1751-8253
1751-7192
DOI:10.1080/17518253.2018.1510991