Comparison between Conventional and Simple Measuring Methods of Mean Nocturnal Baseline Impedance in Pediatric Gastroesophageal Reflux Disease

(1) Background: Multichannel intraluminal impedance-pH (MII-pH) monitoring is commonly used to diagnose gastroesophageal reflux disease (GERD). The mean nocturnal baseline impedance (MNBI) is an important parameter, reflecting the esophageal mucosal integrity and improvement in GERD. This study aims...

Full description

Saved in:
Bibliographic Details
Published inClinics and practice Vol. 14; no. 5; pp. 1682 - 1695
Main Authors Pop, Radu Samuel, Chiperi, Lăcrămioara Eliza, Nechita, Vlad-Ionuț, Man, Sorin Claudiu, Dumitrașcu, Dan Lucian
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.10.2024
MDPI
Subjects
Acids
Age
Catheters
Endoscopy
Esophagus
Gastroesophageal reflux
GERD
impedance-pH monitoring
Methods
MNBI
Patients
pediatric
Pediatrics
Software
United States > US
GERD
MNBI
impedance-pH monitoring
pediatric
Online AccessGet full text

Cover

More Information
Summary:(1) Background: Multichannel intraluminal impedance-pH (MII-pH) monitoring is commonly used to diagnose gastroesophageal reflux disease (GERD). The mean nocturnal baseline impedance (MNBI) is an important parameter, reflecting the esophageal mucosal integrity and improvement in GERD. This study aims to evaluate the correlation between conventionally measured MNBI and a recently described simple MNBI measurement method in diagnosing pediatric GERD. (2) Methods: This prospective observational study enrolled 64 children aged one month to 18 years who underwent 24 h MII-pH monitoring. Conventional MNBI was measured during stable 10 min intervals at night, while the simple MNBI method averaged impedance throughout the nocturnal supine period. (3) Results: Strong correlations were found between conventional and simple MNBI values across all impedance channels in both infants (r > 0.85) and older children (r > 0.9). Conventional and simple MNBIs in the most distal channel (Z6) effectively differentiated non-erosive reflux disease (NERD) from other phenotypes, with AUCs of 0.864 and 0.860, respectively. The simple MNBI demonstrated good diagnostic performance with similar sensitivity and specificity to the conventional MNBI. (4) Conclusions: Including MNBI measurements into routine MII-pH monitoring may enhance GERD diagnosis and reduce the need for more invasive procedures.
ISSN:2039-7275
2039-7283
DOI:10.3390/clinpract14050134