Risk factors of post renal transplant hyperparathyroidism

It is well recognized that patients with end stage renal diseases (ESRD) have hyper-plastic parathyroid glands. In most patients, a decrease in parathyroid hormone (PTH) occurs by about 1 year after renal transplantation. However, some renal transplant recipients continue to have elevated level of P...

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Published inSaudi journal of kidney diseases and transplantation Vol. 20; no. 4; pp. 573 - 576
Main Authors Hamidian Jahromi, Alireza, Roozbeh, Jamshid, Raiss-Jalali, Ghanbar-Ali, Dabaghmanesh, Alireza, Jalaeian, Hamed, Bahador, Ali, Nikeghbalian, Saman, Salehipour, Mehdi, Salahi, Heshmat, Malek-Hosseini, Ali
Format Journal Article
LanguageEnglish
Published Saudi Arabia Medknow Publications and Media Pvt. Ltd 01.07.2009
Wolters Kluwer Medknow Publications
Subjects
Age Factors
Calcium - blood
Humans
Hypercalcemia
Hypercalcemia - epidemiology
Hypercalcemia - physiopathology
Hyperparathyroidism
Kidney Failure, Chronic - blood
Kidney Failure, Chronic - surgery
Kidney Failure, Chronic - therapy
Kidney Transplantation
Parathyroid Hormone - blood
Phosphates - blood
Postoperative Complications - epidemiology
Postoperative Complications - physiopathology
Prospective Studies
Renal Replacement Therapy
Risk factor
Risk Factors
Transplantation
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Summary:It is well recognized that patients with end stage renal diseases (ESRD) have hyper-plastic parathyroid glands. In most patients, a decrease in parathyroid hormone (PTH) occurs by about 1 year after renal transplantation. However, some renal transplant recipients continue to have elevated level of PTH. We prospectively evaluated 121 patients undergoing renal transplantation between August 2000 and 2002. The duration of dialysis, calcium (Ca), phosphorus (P), albumin, creatinine and iPTH levels were recorded prior to transplantation and three months and one year after transplantation. These 121 patients were on dialysis for an average period of 17.4 months prior to transplantation. An increase in the serum Ca and a decrease in serum P and iPTH level was seen in the patients after transplantation (P< 0.001). Hyperparathyroidism was in 12 (9.9%) and 7 (5.7%) patients three months and one year after transplantation respectively. Elderly patients and patients with longer duration on dialysis had an increased risk of developing post transplant hyperpara-thyroidism and hypercalcemia in the first year post transplant (P< 0.05). In conclusion age and duration on dialysis before transplantation seems to be important risk factors for post transplant hyperparathyroidism.
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ISSN:1319-2442