Ca2+ transfer to mitochondria: a spark of life in unexpected conditions

The inositol 1,4,5-triphosphate receptor (InsP3R)-mediated calcium (Ca 2+ ) transfer to mitochondria is important to maintain mitochondrial respiration and bioenergetics in normal and cancer cells, even though cancer cells have defective oxidative phosphorylation (OXPHOS). Here, we discuss how tumor...

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Published inMolecular & cellular oncology Vol. 8; no. 1; p. 1839341
Main Authors Silva-Pavez, Eduardo, Ahumada-Castro, Ulises, Lovy, Alenka, Cárdenas, Julio Cesar
Format Journal Article
LanguageEnglish
Published Taylor & Francis 02.01.2021
Taylor & Francis Group
Subjects
Author’s Views
autophagy
Calcium
cancer
cell survival
OXPHOS
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Summary:The inositol 1,4,5-triphosphate receptor (InsP3R)-mediated calcium (Ca 2+ ) transfer to mitochondria is important to maintain mitochondrial respiration and bioenergetics in normal and cancer cells, even though cancer cells have defective oxidative phosphorylation (OXPHOS). Here, we discuss how tumor mitochondria could become a feasible therapeutic target to treat tumors that depend on reductive carboxylation.
Bibliography:ObjectType-Article-1
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These authors contributed equally to this work
ISSN:2372-3556
2372-3556
DOI:10.1080/23723556.2020.1839341