The complex role of macrophages in pancreatic cancer tumor microenvironment: a review on cancer progression and potential therapeutic targets

Pancreatic cancer (PC) is one of the deadliest cancers worldwide with low survival rates and poor outcomes. The treatment landscape for PC is fraught with obstacles, including drug resistance, lack of effective targeted therapies and the immunosuppressive tumor microenvironment (TME). The resistance...

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Published inDiscover. Oncology Vol. 15; no. 1; pp. 369 - 25
Main Authors Lorestani, Parsa, Dashti, Mohsen, Nejati, Negar, Habibi, Mohammad Amin, Askari, Mandana, Robat-Jazi, Behruz, Ahmadpour, Sajjad, Tavakolpour, Soheil
Format Journal Article
LanguageEnglish
Published New York Springer US 26.08.2024
Springer Nature B.V
Springer
Subjects
Angiogenesis
Antigens
Cancer Research
Cancer therapies
Chemokines
Cytokines
Cytotoxicity
Fibroblasts
Genotype & phenotype
Growth factors
Hypoxia
Immune system
Immunotherapies
Immunotherapy
Internal Medicine
Ligands
Lymphocytes
Macrophage-targeted therapy
Macrophages
Medical prognosis
Medicine
Medicine & Public Health
Molecular Medicine
Oncology
Pancreatic cancer
Pancreatic ductal adenocarcinoma
Radiotherapy
Review
Surgical Oncology
Tumor microenvironment
Tumor necrosis factor-TNF
Tumors
Macrophage-targeted therapy
Tumor microenvironment
Macrophages
Pancreatic cancer
Pancreatic ductal adenocarcinoma
Immunotherapies
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Summary:Pancreatic cancer (PC) is one of the deadliest cancers worldwide with low survival rates and poor outcomes. The treatment landscape for PC is fraught with obstacles, including drug resistance, lack of effective targeted therapies and the immunosuppressive tumor microenvironment (TME). The resistance of PC to existing immunotherapies highlights the need for innovative approaches, with the TME emerging as a promising therapeutic target. The recent advancements in understanding the role of macrophages, this context highlight their significant impact on tumor development and progression. There are two important types of macrophages: M1 and M2, which play critical roles in the TME. Therapeutics strategies including, depletion of tumor-associated macrophages (TAMs), reprogramming TAMs to promote anti-tumor activity, and targeting macrophage recruitment can lead to promising outcomes. Targeting macrophage-related pathways may offer novel strategies for modulating immune responses, inhibiting angiogenesis, and overcoming resistance to chemotherapy in PC treatment.
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ISSN:2730-6011
2730-6011
DOI:10.1007/s12672-024-01256-x