Efficacy and safety of intranasal insulin on postoperative cognitive dysfunction in elderly patients after laparoscopic radical resection of colorectal cancer: a double-blind pilot study

• Published in: Frontiers in aging neuroscience Vol. 16; p. 1375841
• Main Authors: Zhang, Hailong, Zhao, Liqin, Li, Min, Li, Xu, Li, Ruofan, Wu, Di
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 10.06.2024; Frontiers Media S.A
• Subjects: a double-blind pilot study by pilot study; Aging Neuroscience; Allergies; Body mass index; Cancer; Cognitive ability; Colorectal cancer; Colorectal carcinoma; Diabetes; Education; elderly; General anesthesia; Insulin; Interleukin 6; intranasal insulin by intranasal drug; Intubation; Irritation; Laparoscopy; Neuropsychology; Patients; Pilot projects; postoperative cognitive dysfuction by postoperative complications; Serum levels; Statistical analysis; Surgery; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Beijing China; United States > US; China; intranasal insulin by intranasal drug; a double-blind pilot study by pilot study; colorectal cancer; postoperative cognitive dysfuction by postoperative complications; elderly
• ISSN: 1663-4365; 1663-4365
• DOI: 10.3389/fnagi.2024.1375841

To evaluate the efficacy and safety of intranasal insulin on postoperative cognitive dysfunction (POCD) in elderly patients after laparoscopic radical resection of colorectal cancer. Older patients scheduled for laparoscopic radical resection of colorectal cancer at Beijing Luhe Hospital, Capital Medical University, between August 2023 and November 2023, were enrolled in this double-blind pilot study. Patients were randomized to the control and insulin groups at a 1:1 ratio. The primary outcome was the rate of POCD at postoperative 7 days. A total of 61 patients (30 in the insulin group) were analyzed. The insulin group had a significantly lower POCD rate compared with the control group at postoperative day 7 [4(13.3%) vs. 12 (38.7%),  = 0.024]. The serum levels of IL-6, TNF-α and S100β at T in the insulin group were significantly lower than those of the control group (IL-6: mean difference at T , -4.14,  = 0.036; T , -3.84,  = 0.039; T , -3.37,  = 0.013; T , -2.57,  = 0.042; TNF-α: mean difference at T , -3.19,  = 0.002; T , -2.35,  = 0.028; T , -2.30,  = 0.019; T , -1.96,  = 0.0181; S100β: mean difference at T , -8.30,  = 0.019; T , -23.95,  = 0.020; T , -20.01,  = 0.023; T , -17.67,  = 0.010). No insulin allergic reactions, nasal irritation, or hypoglycemic reactions were observed in either of the groups. Intranasal insulin may decrease the risk of POCD and inhibit the elevated serum IL-6, TNF-α, and S100β levels in elderly patients after laparoscopic radical resection of colorectal cancer, which proves that intranasal insulin may be a promising therapeutic option for POCD. Identifier, ChiCTR2300074423.