Antimicrobial and cytotoxic activity of three bitter plants enhydra fluctuans, andrographis peniculata and clerodendrum viscosum

In this study, three important medicinal plants (Enhydra fluctuans Lour, Clerodendrum viscosum Vent and Andrographis peniculata Wall) of Bangladesh were investigated to analyze their antimicrobial and cytotoxic activities against some pathogenic microorganisms and Artemia salina (brine shrimp naupli...

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Bibliographic Details
Published inAdvanced pharmaceutical bulletin Vol. 2; no. 2; pp. 207 - 211
Main Authors Amin, M Ruhul, Mondol, Ripon, Habib, M Rowshanul, Hossain, M Tofazzal
Format Journal Article
LanguageEnglish
Published Iran Tabriz University of Medical Sciences 2012
Subjects
Andrographi speniculata
Antimicrobial
Clerodendrum viscosum
Cytotoxic
Enhydra fluctuans
Antimicrobial
Clerodendrum viscosum
Andrographis peniculata
Enhydra fluctuans
Cytotoxic
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Summary:In this study, three important medicinal plants (Enhydra fluctuans Lour, Clerodendrum viscosum Vent and Andrographis peniculata Wall) of Bangladesh were investigated to analyze their antimicrobial and cytotoxic activities against some pathogenic microorganisms and Artemia salina (brine shrimp nauplii). The coarse powder material of leaves of each plant was extracted separately with methanol and acetone to yield methanol extracts of leaves of Enhydra fluctuans (MLE), Clerodendrum viscosum (MLC) and Andrographis peniculata (MLA), and acetone extracts of leaves of Enhydra fluctuans (ALE), Clerodendrum viscosum (ALC) and Andrographis peniculata (ALA). The disc diffusion method and the method described by Meyer were used to determine the antimicrobial and cytotoxic activities of each plant extract. Among the test samples, MLE and ALE showed comparatively better antimicrobial activity against a number of bacteria and fungi with inhibition zones in the range of 06-15 mm and according to the intensity of activity, the efficacy against microorganisms were found in the order of Enhydra fluctuans > Andrographis peniculata > Clerodendrum viscosum. In cytotoxicity assay, all samples were found to be active against brine shrimp nauplii (Artemia salina) and ALA produced lowest LC50 value (7.03 μg/ml). Enhydra fluctuans and Andrographis peniculata possesses significant antimicrobial and cytotoxic activities.
ISSN:2228-5881
2251-7308
DOI:10.5681/apb.2012.032