Antiarthritic and Antinociceptive Properties of Ylang-Ylang ( Cananga odorata ) Essential Oil in Experimental Models
The aim of this study was to evaluate the effect of ylang-ylang ( ) essential oil (YEO) on models of experimental arthritis, persistent inflammation, and nociception in mice. YEO treatment at doses of 100 and 200 mg/kg reduced the infiltration of leukocytes into the joint cavities of mice submitted...
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| Published in | Current Issues in Molecular Biology Vol. 46; no. 8; pp. 9033 - 9046 |
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| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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01.08.2024
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| Abstract | The aim of this study was to evaluate the effect of ylang-ylang (
) essential oil (YEO) on models of experimental arthritis, persistent inflammation, and nociception in mice. YEO treatment at doses of 100 and 200 mg/kg reduced the infiltration of leukocytes into the joint cavities of mice submitted to zymosan-induced arthritis 6 h and 7 days after arthritis induction. At these doses, YEO treatment reduced the formation of joint edema 4 and 6 h after arthritis induction, and at a dose of 200 mg/kg, YEO treatment reduced mechanical hyperalgesia 3 and 4 h after arthritis induction. At the dose of 200 mg/kg, YEO treatment reduced interleukin-6 (IL-6) levels and cartilage destruction in the zymosan-induced arthritis model, and reduced edema formation and mechanical hyperalgesia in the model of persistent inflammation (21 days) induced by complete Freund's adjuvant (CFA) in mice. YEO treatment at a dose of 200 mg/kg reduced the nociceptive response in experimental models of nociception induced by acetic acid and formalin. The YEO treatment reduced inflammatory parameters in the experimental arthritis model, and presented antiarthritic, anti-hyperalgesic, antinociceptive, and anti-inflammatory properties. |
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| AbstractList | The aim of this study was to evaluate the effect of ylang-ylang (Cananga odorata) essential oil (YEO) on models of experimental arthritis, persistent inflammation, and nociception in mice. YEO treatment at doses of 100 and 200 mg/kg reduced the infiltration of leukocytes into the joint cavities of mice submitted to zymosan-induced arthritis 6 h and 7 days after arthritis induction. At these doses, YEO treatment reduced the formation of joint edema 4 and 6 h after arthritis induction, and at a dose of 200 mg/kg, YEO treatment reduced mechanical hyperalgesia 3 and 4 h after arthritis induction. At the dose of 200 mg/kg, YEO treatment reduced interleukin-6 (IL-6) levels and cartilage destruction in the zymosan-induced arthritis model, and reduced edema formation and mechanical hyperalgesia in the model of persistent inflammation (21 days) induced by complete Freund's adjuvant (CFA) in mice. YEO treatment at a dose of 200 mg/kg reduced the nociceptive response in experimental models of nociception induced by acetic acid and formalin. The YEO treatment reduced inflammatory parameters in the experimental arthritis model, and presented antiarthritic, anti-hyperalgesic, antinociceptive, and anti-inflammatory properties.The aim of this study was to evaluate the effect of ylang-ylang (Cananga odorata) essential oil (YEO) on models of experimental arthritis, persistent inflammation, and nociception in mice. YEO treatment at doses of 100 and 200 mg/kg reduced the infiltration of leukocytes into the joint cavities of mice submitted to zymosan-induced arthritis 6 h and 7 days after arthritis induction. At these doses, YEO treatment reduced the formation of joint edema 4 and 6 h after arthritis induction, and at a dose of 200 mg/kg, YEO treatment reduced mechanical hyperalgesia 3 and 4 h after arthritis induction. At the dose of 200 mg/kg, YEO treatment reduced interleukin-6 (IL-6) levels and cartilage destruction in the zymosan-induced arthritis model, and reduced edema formation and mechanical hyperalgesia in the model of persistent inflammation (21 days) induced by complete Freund's adjuvant (CFA) in mice. YEO treatment at a dose of 200 mg/kg reduced the nociceptive response in experimental models of nociception induced by acetic acid and formalin. The YEO treatment reduced inflammatory parameters in the experimental arthritis model, and presented antiarthritic, anti-hyperalgesic, antinociceptive, and anti-inflammatory properties. The aim of this study was to evaluate the effect of ylang-ylang ( ) essential oil (YEO) on models of experimental arthritis, persistent inflammation, and nociception in mice. YEO treatment at doses of 100 and 200 mg/kg reduced the infiltration of leukocytes into the joint cavities of mice submitted to zymosan-induced arthritis 6 h and 7 days after arthritis induction. At these doses, YEO treatment reduced the formation of joint edema 4 and 6 h after arthritis induction, and at a dose of 200 mg/kg, YEO treatment reduced mechanical hyperalgesia 3 and 4 h after arthritis induction. At the dose of 200 mg/kg, YEO treatment reduced interleukin-6 (IL-6) levels and cartilage destruction in the zymosan-induced arthritis model, and reduced edema formation and mechanical hyperalgesia in the model of persistent inflammation (21 days) induced by complete Freund's adjuvant (CFA) in mice. YEO treatment at a dose of 200 mg/kg reduced the nociceptive response in experimental models of nociception induced by acetic acid and formalin. The YEO treatment reduced inflammatory parameters in the experimental arthritis model, and presented antiarthritic, anti-hyperalgesic, antinociceptive, and anti-inflammatory properties. The aim of this study was to evaluate the effect of ylang-ylang (Cananga odorata) essential oil (YEO) on models of experimental arthritis, persistent inflammation, and nociception in mice. YEO treatment at doses of 100 and 200 mg/kg reduced the infiltration of leukocytes into the joint cavities of mice submitted to zymosan-induced arthritis 6 h and 7 days after arthritis induction. At these doses, YEO treatment reduced the formation of joint edema 4 and 6 h after arthritis induction, and at a dose of 200 mg/kg, YEO treatment reduced mechanical hyperalgesia 3 and 4 h after arthritis induction. At the dose of 200 mg/kg, YEO treatment reduced interleukin-6 (IL-6) levels and cartilage destruction in the zymosan-induced arthritis model, and reduced edema formation and mechanical hyperalgesia in the model of persistent inflammation (21 days) induced by complete Freund’s adjuvant (CFA) in mice. YEO treatment at a dose of 200 mg/kg reduced the nociceptive response in experimental models of nociception induced by acetic acid and formalin. The YEO treatment reduced inflammatory parameters in the experimental arthritis model, and presented antiarthritic, anti-hyperalgesic, antinociceptive, and anti-inflammatory properties. The aim of this study was to evaluate the effect of ylang-ylang ( Cananga odorata ) essential oil (YEO) on models of experimental arthritis, persistent inflammation, and nociception in mice. YEO treatment at doses of 100 and 200 mg/kg reduced the infiltration of leukocytes into the joint cavities of mice submitted to zymosan-induced arthritis 6 h and 7 days after arthritis induction. At these doses, YEO treatment reduced the formation of joint edema 4 and 6 h after arthritis induction, and at a dose of 200 mg/kg, YEO treatment reduced mechanical hyperalgesia 3 and 4 h after arthritis induction. At the dose of 200 mg/kg, YEO treatment reduced interleukin-6 (IL-6) levels and cartilage destruction in the zymosan-induced arthritis model, and reduced edema formation and mechanical hyperalgesia in the model of persistent inflammation (21 days) induced by complete Freund’s adjuvant (CFA) in mice. YEO treatment at a dose of 200 mg/kg reduced the nociceptive response in experimental models of nociception induced by acetic acid and formalin. The YEO treatment reduced inflammatory parameters in the experimental arthritis model, and presented antiarthritic, anti-hyperalgesic, antinociceptive, and anti-inflammatory properties. |
| Audience | Academic |
| Author | Machado, Lucas Luiz Souza, Maria Inês Lenz Felipe, Josyelen Lousada Ferreira, João Victor Toffoli-Kadri, Mônica Cristina Paredes-Gamero, Edgar Julian de Souza, Kamylla Fernanda Souza Lossavaro, Paloma Kênia de Moraes Berenguel Parisotto, Eduardo Benedetti Kassuya, Cândida Aparecida Leite Bonfá, Iluska Senna Fernandes, Mila Marluce Lima Candeloro, Luciane Silva-Filho, Saulo Euclides Lencina, Joyce Dos Santos |
| AuthorAffiliation | 3 Health Sciences College, Federal University of Grande Dourados, Dourados 79804-970, MS, Brazil; candida2005@gmail.com 1 Pharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil; paloma.lossavaro01@gmail.com (P.K.d.M.B.L.); josyfelipe@hotmail.com (J.L.F.); joycedslencina@gmail.com (J.d.S.L.); iluska.senna@ufms.br (I.S.B.); kamylla.bio@outlook.com (K.F.S.d.S.); lucaslmachado11@gmail.com (L.L.M.); mila.fernandes@ufms.br (M.M.L.F.); joao_ferreira@ufms.br (J.V.F.); edgar.gamero@ufms.br (E.J.P.-G.); eduardo.parisotto@ufms.br (E.B.P.); monica.kadri@ufms.br (M.C.T.-K.) 2 Biosciences Institute, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil; maria.souza@ufms.br (M.I.L.S.); lucandeloro@gmail.com (L.C.) |
| AuthorAffiliation_xml | – name: 1 Pharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil; paloma.lossavaro01@gmail.com (P.K.d.M.B.L.); josyfelipe@hotmail.com (J.L.F.); joycedslencina@gmail.com (J.d.S.L.); iluska.senna@ufms.br (I.S.B.); kamylla.bio@outlook.com (K.F.S.d.S.); lucaslmachado11@gmail.com (L.L.M.); mila.fernandes@ufms.br (M.M.L.F.); joao_ferreira@ufms.br (J.V.F.); edgar.gamero@ufms.br (E.J.P.-G.); eduardo.parisotto@ufms.br (E.B.P.); monica.kadri@ufms.br (M.C.T.-K.) – name: 2 Biosciences Institute, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil; maria.souza@ufms.br (M.I.L.S.); lucandeloro@gmail.com (L.C.) – name: 3 Health Sciences College, Federal University of Grande Dourados, Dourados 79804-970, MS, Brazil; candida2005@gmail.com |
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) essential oil (YEO) on models of experimental arthritis, persistent inflammation, and... The aim of this study was to evaluate the effect of ylang-ylang (Cananga odorata) essential oil (YEO) on models of experimental arthritis, persistent... The aim of this study was to evaluate the effect of ylang-ylang ( Cananga odorata ) essential oil (YEO) on models of experimental arthritis, persistent... |
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| SubjectTerms | Acetic acid Analysis Antiarthritic agents Arthritis essential oil Ethylenediaminetetraacetic acid Formaldehyde Inflammation Interleukins natural products Organic acids persistent inflammation ylang-ylang |
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| Title | Antiarthritic and Antinociceptive Properties of Ylang-Ylang ( Cananga odorata ) Essential Oil in Experimental Models |
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