Antiarthritic and Antinociceptive Properties of Ylang-Ylang ( Cananga odorata ) Essential Oil in Experimental Models

• Published in: Current Issues in Molecular Biology Vol. 46; no. 8; pp. 9033 - 9046
• Main Authors: Lossavaro, Paloma Kênia de Moraes Berenguel, Felipe, Josyelen Lousada, Lencina, Joyce Dos Santos, Bonfá, Iluska Senna, de Souza, Kamylla Fernanda Souza, Machado, Lucas Luiz, Fernandes, Mila Marluce Lima, Ferreira, João Victor, Souza, Maria Inês Lenz, Candeloro, Luciane, Kassuya, Cândida Aparecida Leite, Paredes-Gamero, Edgar Julian, Parisotto, Eduardo Benedetti, Toffoli-Kadri, Mônica Cristina, Silva-Filho, Saulo Euclides
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.08.2024; MDPI
• Subjects: Acetic acid; Analysis; Antiarthritic agents; Arthritis; essential oil; Ethylenediaminetetraacetic acid; Formaldehyde; Inflammation; Interleukins; natural products; Organic acids; persistent inflammation; ylang-ylang; Brazil; persistent inflammation; natural products; ylang-ylang; essential oil; arthritis
• ISSN: 1467-3037; 1467-3045; 1467-3045
• DOI: 10.3390/cimb46080534

The aim of this study was to evaluate the effect of ylang-ylang ( ) essential oil (YEO) on models of experimental arthritis, persistent inflammation, and nociception in mice. YEO treatment at doses of 100 and 200 mg/kg reduced the infiltration of leukocytes into the joint cavities of mice submitted to zymosan-induced arthritis 6 h and 7 days after arthritis induction. At these doses, YEO treatment reduced the formation of joint edema 4 and 6 h after arthritis induction, and at a dose of 200 mg/kg, YEO treatment reduced mechanical hyperalgesia 3 and 4 h after arthritis induction. At the dose of 200 mg/kg, YEO treatment reduced interleukin-6 (IL-6) levels and cartilage destruction in the zymosan-induced arthritis model, and reduced edema formation and mechanical hyperalgesia in the model of persistent inflammation (21 days) induced by complete Freund's adjuvant (CFA) in mice. YEO treatment at a dose of 200 mg/kg reduced the nociceptive response in experimental models of nociception induced by acetic acid and formalin. The YEO treatment reduced inflammatory parameters in the experimental arthritis model, and presented antiarthritic, anti-hyperalgesic, antinociceptive, and anti-inflammatory properties.