Use of Guazuma ulmifolia Lam. Stem Bark Extracts to Prevent High-Fat Diet Induced Metabolic Disorders in Mice

• Published in: International journal of molecular sciences Vol. 25; no. 16; p. 8889
• Main Authors: Rodrigues, Elisana Lima, Santana, Lidiani Figueiredo, Nascimento, Valter Aragão do, Arakaki, Marcel Asato, Cardoso, Claudia Andréa Lima, Filiú, Wander Fernando de Oliveira, Guimarães, Rita de Cássia Avellaneda, Hiane, Priscila Aiko, Freitas, Karine de Cássia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 15.08.2024; MDPI
• Subjects: Adipocytes; Animals; Antioxidants; Antioxidants - pharmacology; Apocynaceae - chemistry; Blood Glucose - drug effects; Body fat; Diet; Diet, High-Fat - adverse effects; Energy; Flavonoids; Food; high-fat diet; Hormones; Insulin; Male; medicinal plants; Metabolic Diseases - drug therapy; Metabolic Diseases - etiology; Metabolic Diseases - prevention & control; Metabolic disorders; Metabolites; Mice; Mice, Inbred C57BL; phenolic compounds; Phytochemicals; Plant Bark - chemistry; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Stems - chemistry; Toxicity; phenolic compounds; medicinal plants; antioxidants; high-fat diet
• ISSN: 1661-6596; 1422-0067; 1422-0067
• DOI: 10.3390/ijms25168889

This study aimed to evaluate the effects of supplementation with ethanolic and aqueous extracts from the bark of the stem of in mice submitted to a high-fat diet as well as to evaluate the chemical composition of these extracts. The chemical composition and antioxidant potential was evaluated in aqueous and ethanolic extracts of the stem bark. The in vivo test consisted of evaluating the effects of the aqueous and ethanolic extracts of the stem bark on C57BL/6 mice receiving a high-fat diet. The animals were evaluated for weight gain, feed consumption, visceral adiposity, serum, and inflammatory and hormonal parameters. The results of the chemical analyses corroborate those obtained by the literature, which reported gallocatechin, epigallocatechin and epigallocatechin gallate. Compared with the ethanolic extract, the aqueous extract showed greater antioxidant capacity. Both extracts resulted in lower feed consumption in the animals, but they did not influence weight gain or visceral adiposity and resulted in varied changes in the lipid profile. In addition, they did not influence glucose tolerance, insulin sensitivity, or fasting blood glucose. Furthermore, the leptin levels increased, which may have contributed to satiety, but this was shown to have a negative impact on other inflammatory and hormonal parameters. Therefore, under the conditions of this study, the biologically active compounds present in the plant species were not able to contribute to the treatment of metabolic changes related to the consumption of a high-fat diet.