Two Cases of Increased Gastrointestinal Polyps in Familial Adenomatous Polyposis following Antiacid Agent Intake

• Published in: Case reports in gastroenterology Vol. 18; no. 1; pp. 293 - 298
• Main Authors: Urabe, Yuji, Ishikawa, Hideki, Ishikawa, Akira, Ishiguro, Shingo, Ishibashi, Kazuki, Arihiro, Koji, Mutoh, Michihiro, Oka, Shiro
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2024; Karger Publishers
• Subjects: Anemia; Antacids; Biopsy; Case reports; Case Series; Cell growth; colon adenoma; Colonoscopy; Colorectal cancer; Endoscopy; familial adenomatous polyposis; fundic gland polyps; Gastroesophageal reflux; Genetic disorders; Histamine; Hyperplasia; Patients; Polyps; potassium-competitive acid blocker (vonoprazan); proton pump inhibitor; Surveillance; Tumors; Colon adenoma; Potassium-competitive acid blocker (vonoprazan); Fundic gland polyps; Familial adenomatous polyposis; Proton pump inhibitor
• ISSN: 1662-0631; 1662-0631
• DOI: 10.1159/000538833

Abstract Introduction: Familial adenomatous polyposis (FAP), a hereditary disorder of the gastrointestinal tract, is an autosomal dominant inherited condition caused by germline mutations in the adenomatous polyposis coli (APC) gene. It is characterized by the development of hundreds to thousands of colorectal adenomatous polyps, which, if left untreated, can eventually develop into colorectal carcinomas. Representative extracolonic tumors in FAP include multiple duodenal adenomas and desmoid tumors. Moreover, multiple fundic gland polyps are frequently identified in the stomachs of patients with FAP. Case Presentation: Herein, we report the two cases. A 52-year-old woman who underwent total colectomy for FAP, and pancreatoduodenectomy was initiated on esomeprazole for the treatment of anastomotic erosion. Esophagogastroduodenoscopy performed 42 months later showed an increased number and size of gastric fundic gland polyps, which subsequently decreased after replacing esomeprazole with ranitidine. Similarly, a 39-year-old woman with FAP was initiated on vonoprazan for the treatment of reflux symptoms. Esophagogastroduodenoscopy and colonoscopy performed 14 months later indicated an increase in the number of gastric fundic gland polyps and colorectal polyps, which subsequently decreased after vonoprazan discontinuation. In these two cases, the increase and decrease in the number and size of fundic gland polyps and colon adenoma were associated with serum gastrin levels. Conclusion: Gastric fundic gland polyps and colon polyps may rapidly increase in number and size due to increased gastrin levels induced by proton pump inhibitor/potassium-competitive acid blocker use. Hence, these drugs should be prescribed with caution.