Effect of phthalocyanine oral and nasal antiseptic solutions on the infectivity of SARS-CoV-2 in patients with COVID-19: a randomized controlled trial

• Published in: German medical science Vol. 21; p. Doc07
• Main Authors: Colado Simão, Andréa Name, Perugini Stadtlober, Nicole, Stinghen Garcia Lonni, Audrey Alesandra, Venâncio, Luiza Mara, Lerner Trigo, Guilherme, de Souza Cassela, Pedro Luis Candido, Mastellini Sanches Silva, Thais, De Fátima Oliveira Hirth Ruiz, Maria, Batisti Lozovoy, Marcell Alysson, Tano, Zuleica Naomi, da Fonseca Orcina, Bernardo, Vieira Vilhena, Fabiano, da Silva Santos, Paulo Sérgio
• Format: Journal Article
• Language: English
• Published: Germany German Medical Science GMS Publishing House 2023
• Subjects: Anti-Infective Agents, Local - therapeutic use; COVID-19; Humans; infectivity; mouthwashes; Mouthwashes - therapeutic use; Nasal Sprays; phthalocyanine; SARS-CoV-2; sars-cov-2 infection; COVID-19; SARS-CoV-2 infection; mouthwashes; phthalocyanine; infectivity
• ISSN: 1612-3174; 1612-3174
• DOI: 10.3205/000321

In individuals with coronavirus disease (COVID-19), the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load (VL) plays an important role in infectivity. This study aimed to evaluate the reduction in the VL and infectivity induced by phthalocyanine mouthwash and nasal spray in patients with COVID-19. Patients with mild COVID-19 were recruited to participate in a triple-blinded randomized controlled trial. Participants were assigned to one of three groups: Group 1, non-active mouthwash and saline nasal spray (SNS); Group 2, phthalocyanine mouthwash and SNS; and Group 3 phthalocyanine mouthwash and phthalocyanine nasal spray. VL was assessed in nasopharyngeal and oropharyngeal swabs collected at the time of clinical diagnosis at baseline as well as 24 and 72 hours after starting the rinsing protocols. Forty-six participants were included in the analysis: 15, 16, and 15 in Groups 1, 2, and 3, respectively. After 72 hours, the reduction in VL was significantly higher in Group 3 (mean cycle threshold (Ct) decrease: 11.21) than in Group 1 (mean Ct decrease: 5.53). Additionally, only the mean VL in Group 3 was reduced to a non-contagious level after 72 hours. Use of phthalocyanine mouthwash and nasal spray is effective at reducing SARS-CoV-2 infectivity.