A case report on Madelung's disease and comprehensive review of the literature

• Published in: Orphanet journal of rare diseases Vol. 19; no. 1; pp. 302 - 7
• Main Authors: Jiao, Cheng, Liu, Wei, Qiao, Yiming, Qi, Shuai, Shen, Yifei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.08.2024; BMC
• Subjects: Adipose tissues; Benign symmetric lipomatosis; Care and treatment; Case studies; Connective tissue tumors; Diagnosis; Diseases; Female; Health aspects; Humans; Lipid metabolism; Lipomatosis, Multiple Symmetrical - diagnosis; Lipomatosis, Multiple Symmetrical - pathology; Lipomatosis, Multiple Symmetrical - surgery; Liposuction surgery; Madelung’s disease; Medical imaging equipment; Medical research; Medicine, Experimental; Middle Aged; Physiological aspects; Surgical treatment; China; Lipid metabolism; Madelung’s disease; Benign symmetric lipomatosis; Surgical treatment; Liposuction surgery
• ISSN: 1750-1172; 1750-1172
• DOI: 10.1186/s13023-024-03303-w

Madelung's disease (MD), alternatively referred to as benign symmetric lipomatosis, multiple symmetric lipomatosis, or Launois-Bensaude syndrome, is an uncommon benign disorder marked by symmetric proliferation of adipose tissue in the head, neck, and torso regions. In this case, the patient was a female with the late middle-aged demographic, diagnosed with Type I MD. Notably, she exhibited no prior history of alcohol consumption, and there was no family history of MD. Subsequent to the clinical diagnosis, the patient underwent medical imaging assessments to delineate the surgical parameters. Post-surgery, she demonstrated a favorable recovery trajectory, marked by the absence of any surgical complications. The patient underwent successful surgical excision of the lipomatous mass. Postoperatively, she had an uneventful recovery with no complications and no recurrence observed during the follow-up period of seven months. Timely diagnosis and early surgical intervention play a pivotal role in enhancing the quality of life for individuals with MD. Preoperative medical imaging examinations function as highly effective tools, contributing to heightened surgical safety and a decreased probability of encountering complications during the surgical procedure.