Case report: Rapid clinical improvement in acute exacerbation of MuSK-MG with efgartigimod
Myasthenia gravis with positive MuSK antibody often involves the bulbar muscles and is usually refractory to acetylcholinesterase inhibitors. For MuSK-MG patients who experience acute exacerbations and do not respond to conventional treatments, there is an urgent need to find more suitable treatment...
Saved in:
Published in | Frontiers in immunology Vol. 15; p. 1401972 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
07.06.2024
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Myasthenia gravis with positive MuSK antibody often involves the bulbar muscles and is usually refractory to acetylcholinesterase inhibitors. For MuSK-MG patients who experience acute exacerbations and do not respond to conventional treatments, there is an urgent need to find more suitable treatment options. With the advent of biologic agents, efgartigimod has shown promising results in the treatment of MG. We report a 65-year-old MuSK-MG patient who presented with impaired eye movements initially, and the symptoms rapidly worsened within a week, affecting the limbs and neck muscles, and had difficulties in chewing and swallowing. Lymphoplasmapheresis did not achieve satisfactory results, but after a cycle of efgartigimod treatment, the patient's symptoms gradually improved and remained in a good clinical state for several months. |
---|---|
Bibliography: | ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 Reviewed by: Mehdi Benamar, Harvard Medical School, United States Edited by: Prashanth Ramachandran, The University of Melbourne, Australia Seung Woo Kim, Yonsei University, Republic of Korea |
ISSN: | 1664-3224 1664-3224 |
DOI: | 10.3389/fimmu.2024.1401972 |