Histone modifications and their roles in macrophage-mediated inflammation: a new target for diabetic wound healing

Impaired wound healing is one of the main clinical complications of type 2 diabetes (T2D) and a major cause of lower limb amputation. Diabetic wounds exhibit a sustained inflammatory state, and reducing inflammation is crucial to diabetic wounds management. Macrophages are key regulators in wound he...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in immunology Vol. 15; p. 1450440
Main Authors Wang, Jing, Feng, Jiawei, Ni, Yiming, Wang, Yuqing, Zhang, Ting, Cao, Yemin, Zhou, Mingmei, Zhao, Cheng
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 20.08.2024
Subjects
Animals
Diabetes Mellitus, Type 2 - immunology
Diabetes Mellitus, Type 2 - metabolism
diabetic wounds
histone acetylation
Histone Code
histone methylation
histone modifications
histone-modifying enzymes
Histones - metabolism
Humans
Immunology
Inflammation - immunology
Inflammation - metabolism
macrophage
Macrophages - immunology
Macrophages - metabolism
Wound Healing - immunology
histone methylation
macrophage
histone modifications
histone acetylation
diabetic wounds
histone-modifying enzymes
Online AccessGet full text

Cover

More Information
Summary:Impaired wound healing is one of the main clinical complications of type 2 diabetes (T2D) and a major cause of lower limb amputation. Diabetic wounds exhibit a sustained inflammatory state, and reducing inflammation is crucial to diabetic wounds management. Macrophages are key regulators in wound healing, and their dysfunction would cause exacerbated inflammation and poor healing in diabetic wounds. Gene regulation caused by histone modifications can affect macrophage phenotype and function during diabetic wound healing. Recent studies have revealed that targeting histone-modifying enzymes in a local, macrophage-specific manner can reduce inflammatory responses and improve diabetic wound healing. This article will review the significance of macrophage phenotype and function in wound healing, as well as illustrate how histone modifications affect macrophage polarization in diabetic wounds. Targeting macrophage phenotype with histone-modifying enzymes may provide novel therapeutic strategies for the treatment of diabetic wound healing.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
Uzma Saqib, Indian Institute of Technology Indore, India
Reviewed by: Fotios Karagiannis, University Hospital Bonn, Germany
Edited by: Janos G. Filep, Montreal University, Canada
These authors have contributed equally to this work
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2024.1450440