Exosomal noncoding RNAs: decoding their role in thyroid cancer progression

Exosomes, as pivotal entities within the tumor microenvironment, orchestrate intercellular communication through the transfer of diverse molecules, among which non-coding RNAs (ncRNAs) such as miRNAs, lncRNAs, and circRNAs play a crucial role. These ncRNAs, endowed with regulatory functions, are sel...

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Published inFrontiers in endocrinology (Lausanne) Vol. 15; p. 1337226
Main Authors Sun, Weiming, Jiang, Chenjun, Liu, Qianqian, Wang, Na, Huang, Runchun, Jiang, Gengchen, Yang, Yuxuan
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 12.06.2024
Subjects
Animals
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
circRNAs
Disease Progression
Endocrinology
Epithelial-Mesenchymal Transition
exosomes
Exosomes - genetics
Exosomes - metabolism
Gene Expression Regulation, Neoplastic
Humans
lncRNAs
miRNAs
noncoding RNAs
RNA, Untranslated - genetics
thyroid cancer
Thyroid Neoplasms - genetics
Thyroid Neoplasms - metabolism
Thyroid Neoplasms - pathology
Tumor Microenvironment
lncRNAs
circRNAs
thyroid cancer
miRNAs
noncoding RNAs
exosomes
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Summary:Exosomes, as pivotal entities within the tumor microenvironment, orchestrate intercellular communication through the transfer of diverse molecules, among which non-coding RNAs (ncRNAs) such as miRNAs, lncRNAs, and circRNAs play a crucial role. These ncRNAs, endowed with regulatory functions, are selectively incorporated into exosomes. Emerging evidence underscores the significance of exosomal ncRNAs in modulating key oncogenic processes in thyroid cancer (TC), including proliferation, metastasis, epithelial-mesenchymal transition (EMT), angiogenesis, and immunoediting. The unique composition of exosomes shields their cargo from enzymatic and chemical degradation, ensuring their integrity and facilitating their specific expression in plasma. This positions exosomal ncRNAs as promising candidates for novel diagnostic and prognostic biomarkers in TC. Moreover, the potential of exosomes in the therapeutic landscape of TC is increasingly recognized. This review aims to elucidate the intricate relationship between exosomal ncRNAs and TC, fostering a deeper comprehension of their mechanistic involvement. By doing so, it endeavors to propel forward the exploration of exosomal ncRNAs in TC, ultimately paving the way for innovative diagnostic and therapeutic strategies predicated on exosomes and their ncRNA content.
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Edited by: Marek Dedecjus, Maria Sklodowska Curie Institute of Oncology, Poland
Reviewed by: Shailendra Kumar Maurya, Virginia Commonwealth University, United States
Yuquan Chen, Monash University, Australia
These authors have contributed equally to this work and share first authorship
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2024.1337226