Synergistic Effect of SiO2 and Fe3O4 Nanoparticles in Autophagy Modulation

• Published in: Nanomaterials (Basel, Switzerland) Vol. 14; no. 12; p. 1033
• Main Authors: Nanda, Sitansu Sekhar, Kim, Danyeong, Yang, Hyewon, An, Seong Soo A, Yi, Dong Kee
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 15.06.2024; MDPI
• Subjects: Antibiotics; Apoptosis; Arthritis; Autophagy; Cell fate; Cell growth; Cell proliferation; iron oxide; Iron oxides; Medical treatment; Nanomaterials; Nanoparticles; Nanotechnology; Physiology; Quantum dots; Reactive oxygen species; ROS; Silica; Silicon dioxide; Synergistic effect; Toxicity; United States > US; South Korea
• ISSN: 2079-4991; 2079-4991
• DOI: 10.3390/nano14121033

Rapid advancements in nanotechnology have expanded its applications and synergistic impact on modern nanosystems. The comprehensive assessment of nanomaterials’ safety for human exposure has become crucial and heightened. In addition to the characterization of cell proliferation and apoptosis, probing the implication of autophagy is vital for understanding the ramification of nanomaterials. Hence, HEK-293 kidney cells were employed to understand the changes in induction and perturbation of autophagy in cells by iron oxide (Fe3O4) and silica (SiO2) nanoparticles. Interestingly, Fe3O4 worked as a potent modulator of the autophagy process through its catalytic performance, which can develop better than that of SiO2 nanoparticles mechanism, stressing their therapeutic implication in the understanding of cell behaviors. The quantification of reactive oxygen species (ROS) was measured along with the process of autophagy during cell growth. This modulated autophagy will help in cell fate determination in complementary therapy for disease treatment, provide a clinical strategy for future study.