Reversible renal failure hypertensive idiopathic nephrotics treated with captopril

• Published in: Saudi journal of kidney diseases and transplantation Vol. 17; no. 2; pp. 216 - 221
• Main Authors: Olowu, Wasiu Adekunle, Adenowo, Olusola A., al-Lusiyan, Jerome B. E.
• Format: Journal Article
• Language: English
• Published: Riyadh, Saudi Arabia Saudi Center for Organ Transplantation 2006; Wolters Kluwer Medknow Publications
• Subjects: Acute Kidney Injury - chemically induced; Acute renal failure; Adolescent; Captopril; Captopril - adverse effects; Child; Cyclophosphamide; Female; Glomerulonephritis, Membranoproliferative - complications; Humans; Hypertension; Hypertension - chemically induced; Male; Nephrotic syndrome; Nephrotic Syndrome - drug therapy; Oliguria; Prednisolone - adverse effects; Proteinuria; Seizures; ارتفاع ضغط الدم; اضطرابات الدورة الدموية; الأمراض; الإنزيم المحول للأنجيوتنسين; الفشل الكلوي; الكلى; المضاعفات; حاصرات ألفا الأدرينالية; علم المداواة; كابتوبريل
• ISSN: 1319-2442; 2320-3838

Angiotensin converting enzyme inhibitor (ACEI)-induced acute renal failure (ARF) is not as commonly reported in children as in adults. We report two cases of idiopathic nephrotic syndrome that developed ARF following captopril (an ACEI) treatment for prednisolone-induced hypertension. The two cases further alert us to the potential risk of ACEI-induced ARF in any nephrotic child on ACEI treatment. Low or high dose ACEIs should be given with extreme caution in active nephrotics in view of their relative hypovolemic state that may provoke ARF. The nephrotic children, who must be treated with ACEIs with or without diuretics, should be closely monitored for the development of ARF during the use of ACEIs.