The Other Side of the Perfect Cup: Coffee-Derived Non-Polyphenols and Their Roles in Mitigating Factors Affecting the Pathogenesis of Type 2 Diabetes

• Published in: International journal of molecular sciences Vol. 25; no. 16; p. 8966
• Main Authors: Ramerth, Alexis, Chapple, Brooke, Winter, Jeremiah, Moore, William
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.08.2024; MDPI
• Subjects: Adipocytes; alkaloids; Animals; Apoptosis; Body fat; caffeine; Cardiovascular disease; Chemokines; Coffee; Coffee - chemistry; Cytokines; Diabetes; Diabetes Mellitus, Type 2 - metabolism; Fatty acids; Glucose; Humans; Hypoxia; Inflammation; Insulin Resistance; Kinases; Ligands; Neutrophils; Obesity; Oxidative stress; Oxidative Stress - drug effects; Pathogenesis; Phosphorylation; Polyphenols; Polyphenols - chemistry; Polyphenols - pharmacology; Polyphenols - therapeutic use; Proteins; Review; Tumor necrosis factor-TNF; type 2 diabetes; caffeine; type 2 diabetes; inflammation; theophylline; alkaloids; coffee; theobromine; oxidative stress
• ISSN: 1661-6596; 1422-0067; 1422-0067
• DOI: 10.3390/ijms25168966

The global prevalence of type 2 diabetes (T2D) is 10.5% among adults in the age range of 20-79 years. The primary marker of T2D is persistent fasting hyperglycemia, resulting from insulin resistance and β-cell dysfunction. Multiple factors can promote the development of T2D, including obesity, inflammation, and oxidative stress. In contrast, dietary choices have been shown to prevent the onset of T2D. Oatmeal, lean proteins, fruits, and non-starchy vegetables have all been reported to decrease the likelihood of T2D onset. One of the most widely consumed beverages in the world, coffee, has also demonstrated an impressive ability to reduce T2D risk. Coffee contains a diverse array of bioactive molecules. The antidiabetic effects of coffee-derived polyphenols have been thoroughly described and recently reviewed; however, several non-polyphenolic molecules are less prominent but still elicit potent physiological actions. This review summarizes the effects of select coffee-derived non-polyphenols on various aspects of T2D pathogenesis.