Morphographic Changes in the Electrocardiogram of Colossoma macropomum Caused by Exposure to Manganese

• Published in: International journal of molecular sciences Vol. 25; no. 16; p. 8910
• Main Authors: Nascimento, Lorena Meirelis do, Dos Santos, Murilo Farias, Paz, Clarissa Araújo da, de Araújo, Daniella Bastos, Ferreira, Rayllan da Cunha, Deiga, Yris da Silva, de Souza, Luana Vasconcelos, Câmara, Tays Mata, Dos Santos, Rodrigo Gonçalves, Barbosa, Anara de Sousa, Hamoy, Maria Klara Otake, do Amaral, Anthony Lucas Gurgel, Eiró-Quirino, Luciana, Cabral, Tárcio Dos Santos, da Silva, Maria Adrina Paixão de Souza, Muto, Nilton Akio, Hamoy, Moisés
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.08.2024; MDPI
• Subjects: Animals; Biomarkers; Cardiac arrhythmia; Cardiac function; Colossoma macropomum; ECG; Electrocardiography; Enzymes; Heart - drug effects; Heart - physiology; Heart rate; Heart Rate - drug effects; manganese; Manganese - toxicity; Manganese Poisoning; Mitochondria; morphographic changes; Colossoma macropomum; ECG; manganese; morphographic changes
• ISSN: 1661-6596; 1422-0067; 1422-0067
• DOI: 10.3390/ijms25168910

Manganese (Mn ) is an abundant chemical element in the earth's crust and is present in soil, water, and industrial environments, including mining, welding, and battery manufacturing. Manganese (Mn) is an essential metal needed as a cofactor for many enzymes to maintain proper biological functions. Excessive exposure to Mn in high doses can result in a condition known as manganism, which results in disorders of the neurological, cardiac, and pulmonary systems. The aim of this study was to assess cardiac susceptibility to manganese intoxication in subjected to a fixed concentration of 4 mg/mL for a period of up to 96 h. This study used 45 Tambaquis (30.38 ± 3.5 g) divided into five groups of 9 animals/treatment. The treated groups were exposed to the manganese concentration for a period of 24, 48, 72, and 96 h, after which the animals' ECGs were recorded, showing heart rate, R-R interval, P-Q interval, QRS complex duration and S-T interval. The results showed that cardiac activity decreased as the contact time increased, with an increase in the P-Q and S-T intervals. This indicates that the breakdown of circulatory homeostasis in these animals was caused by contact time with manganese.