The Management of Cytokine Storm in COVID-19

Cytokine storm in COVID-19 infection is an excessive immune response to external stimuli where the pathogenesis is complex. The disease progresses rapidly and the mortality is high. Certain evidence shows that the severe deterioration of some patients has been closely related to the strong upregulat...

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Bibliographic Details
Published inActa medica Indonesiana Vol. 52; no. 3; pp. 306 - 313
Main Authors Rumende, Cleopas Martin, Susanto, Erwin C, Sitorus, Truely P
Format Journal Article
LanguageEnglish
Published Indonesia Interna Publishing 01.07.2020
Subjects
Betacoronavirus
Coronavirus Infections - blood
Coronavirus Infections - epidemiology
Coronavirus Infections - immunology
COVID-19
cytokine storm
Cytokines - blood
Cytokines - immunology
Disease Management
Humans
hyperinflammation
Immunity, Innate
Pandemics
Pneumonia, Viral - blood
Pneumonia, Viral - epidemiology
Pneumonia, Viral - immunology
SARS-CoV-2
COVID-19
hyperinflammation
cytokine storm
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Summary:Cytokine storm in COVID-19 infection is an excessive immune response to external stimuli where the pathogenesis is complex. The disease progresses rapidly and the mortality is high. Certain evidence shows that the severe deterioration of some patients has been closely related to the strong upregulation of cytokine production in SARS-Co-V2 induced pneumonia with an associated cytokine storm syndrome. Identification of existing approaved therapy with proven safety profile to treat hyperinflammation is critical unmet need in order to reduce COVID-19 associated mortality. To date, no specific therapeutic drugs are available to treat COVID-19 infection. Preliminary studies have shown that immune-modulatory or immune suppressive treatments might be considered as treatment choices for COVID-19, particularly in severe disease. This article review the pathogenesis and treatment strategies of COVID-19 virus-induced inflammatory storm in attempt to provide valuable medication guidance for clinical treatment.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0125-9326
2338-2732