Administration of the immunomodulatory drug aminodihydrophthalazinedione sodium for prevention of progression pneumonia induced COVID-19

• Published in: Terapevtic̆eskii arhiv Vol. 92; no. 11; pp. 65 - 70
• Main Authors: Svistunov, A A, Makhnach, G K, Bunina, D V, Khorobrykh, T V, Volgin, M V, Agadzhanov, V G, Mishchenko, N P, Gandybina, E G
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) "Consilium Medicum" Publishing house 26.12.2020
• Subjects: aminodihydrophthalazinedione sodium; Coronavirus Infections; COVID-19 - drug therapy; covid-induced pneumonia; Female; galavit; Humans; Male; Middle Aged; Pharmaceutical Preparations; pneumofibrosis; Pneumonia, Viral - drug therapy; respiratory failure; SARS-CoV-2; Sodium; respiratory failure; aminodihydrophthalazinedione sodium; COVID-induced pneumonia; Galavit; SARS-CoV-2; pneumofibrosis
• ISSN: 0040-3660; 2309-5342
• DOI: 10.26442/00403660.2020.11.000820

Aim to determine the efficacy of drug aminodihydrophthalazinedione sodium (Galavit) for prevention of progression of the coronavirus infection pulmonary complications: acceleration of regression of pulmonary infiltrates and resolution of COVID-induced pneumonia. 22 patients with medium and severe COVID-induced pneumonia were included in the study. The study included 8 men and 14 women, the average age was 62.17.4 years. Patients with more than one adverse prognostic factor made 82%. Average volume of pulmonary tissue affection (computer tomography CT-2, 2550% of lung volume) was registered in 13 (59.1%) patients, significant volume (CT-3, 5075% of lung volume), in 9 (40.9%) patients. All patients had progressive respiratory failure manifestations due to hypoxemia and related diseases. Aminodihydrophthalazinedione sodium was administered for 714 days from the beginning of disease, at the end of the course of standard complex therapy, in case of preservation of signs of intoxication, negative dynamics according to computer tomography data. Administration of aminodihydrophthalazinedione sodium had a positive effect on the dynamics of clinical scores. The progression of respiratory failure was halted and there was an increase in SpO2 values. According to the control computer tomography data the stabilization of the pulmonary parenchyma affection degree was noted, as well as reduction of the size of the compacted areas in the pulmonary tissue and formation of the picture of organising pneumonia that contributed to reduction of respiratory failure grade. The use of aminodihydrophthalazinedione sodium in complex therapy of COVID-induced pneumonia has a modulating effect on the immune system, prevents the progression of pulmonary tissue affection, promotes regression of infiltration foci, preventing the development of excessive pneumofibrosis and the progression of respiratory failure.