Strain-release driven reactivity of a chiral SuFEx reagent provides stereocontrolled access to sulfinamides, sulfonimidamides, and sulfoximines

• Published in: Nature communications Vol. 15; no. 1; pp. 7001 - 12
• Main Authors: Athawale, Paresh R., Shultz, Zachary P., Saputo, Alexandra, Hall, Yvonne D., Lopchuk, Justin M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.08.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 140/131; 639/638/403/933; 639/638/549/933; 639/638/549/972; 639/638/549/975; Catalysis; Chemical synthesis; Chemistry; Foundation construction; Humanities and Social Sciences; Modular structures; multidisciplinary; Pharmaceutical sciences; Reagents; Science; Science (multidisciplinary); Specialty products; Sulfur
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-024-51224-w

Efforts aimed at enriching the chemical and structural diversity of small molecules have invigorated synthetic exploration in the last two decades. Spatially defined molecular functionality serves as the foundation to construct unique chemical space to further advance discovery science. The chiral SuFEx reagent t -BuSF provides a modular platform for the stereocontrolled bifunctionalization of sulfur. Here we report a third functional feature of t -BuSF enabled by carbamoyl torsional strain-release that further expands the S(IV) and S(VI) chemical space accessible as showcased in over seventy examples, multiple applications in medicinal chemistry, organocatalysis, and diversity-oriented synthesis. The methods presented herein allow for rapid asymmetric diversification around a stereodefined sulfur center with readily available building blocks, improving upon the current state-of-the-art for sulfinyl and sulfonimidoyl synthesis. Spatially defined molecular functionality serves as the foundation to construct unique chemical space to further advance discovery science. Herein the authors report a third functional feature of t-BuSF enabled by carbamoyl torsional strain-release that further expands the S(IV) and S(VI) chemical space.