Outcomes of pregnancy in Wilson's disease: a population-based study from multiple centres of the Han population in China

• Published in: Frontiers in medicine Vol. 11; p. 1436828
• Main Authors: Rao, Rao, Yu, Xu-En, Zhou, Zhi-Hua, Shu, Shan, Du, Yi-Gang, Han, Yong-Zhu, Han, Yong-Sheng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 2024
• Subjects: outcome of pregnancy; prediction; retrospective study; urinary copper; Wilson’s disease; prediction; urinary copper; Wilson’s disease; outcome of pregnancy; retrospective study
• ISSN: 2296-858X; 2296-858X
• DOI: 10.3389/fmed.2024.1436828

Wilson's disease is an autosomal recessive disorder related to copper metabolism which mostly patients occurs in adolescents, fertility has become a problem that WD needs to face. A 21 years retrospective follow up study was conducted and a total of 220 female patients were included to identify patients with outcomes of pregnancy. Untreated female patients with WD had a spontaneous abortion rate of 44%. During the study period, 146 female patients with WD from multicenter, 75 patients (51.4%) had successful outcomes of pregnancy. Notably, urinary copper levels below 616 μg/24 h were strongly associated with successful pregnancy. The nomogram built on these variables were age, urinary copper, haemoglobin and Child-Pugh classification, internally validated and showed good performance. The spontaneous abortion rate was 44% in untreated females with WD and developed a four-variable risk prediction model to accurately predict the likelihood of a successful pregnancy.