The influence of nutritional status and disease on adiponectin and TNF-α; levels in colorectal cancer patients

• Published in: Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral Vol. 30; no. 1; pp. 140 - 146
• Main Authors: Abe Vicente, Mariana, Donizetti Silva, Tiago, Barão, Katia, Vitor Felipe, Aledson, Oyama Missae, Lila, Manoukian Forones, Nora
• Format: Journal Article
• Language: English; Portuguese
• Published: Spain Grupo Arán 01.07.2014; Arán Ediciones, S. L
• Subjects: Adipocitocinas; Adiponectin - blood; Colorectal Neoplasms - blood; Colorectal Neoplasms - pathology; Colorectal Neoplasms - physiopathology; Cross-Sectional Studies; Cáncer colorrectal; Evaluación nutricional; Female; Humans; Male; Middle Aged; Neoplasm Staging; Nutrition & Dietetics; Nutritional Status; Tumor Necrosis Factor-alpha - blood; Adipocytokines; Colorectal Cancer; Adipocitocinas; Cáncer colorrectal; Evaluación nutricional; Nutrition Assessment
• ISSN: 1699-5198; 0212-1611; 1699-5198
• DOI: 10.3305/nh.2014.30.1.7132

The aim of this study was to evaluate the association between adiponectin and tumor necrosis factor-α;(TNF-α;) serum levels in colorectal cancer (CRC) patients and compare these levels to clinical stage and nutritional status. A total of 79 patients were enrolled in the study (39 with CRC and 40 in the control). Nutritional status was assessed by Patient-Generated Subjective Global Assessment (PG-SGA), body mass index (BMI), and phase angle (PhA). Adiponectin and TNF-α;serum concentrations were determined using an enzyme-linked immunosorbent assay. Serum adiponectin levels were higher among CRC patients (p = 0.001). TNF-α;serum levels were not significantly different between the groups, but patients with stage III or IV CRC had higher levels of TNF-α;than those with lower stage disease (p = 0.037). The three tools used for the assessment of nutritional status (BMI, PhA, and PG-SGA) demonstrated that patients with a more severe nutritional deficit had higher adipocytokine levels, although these differences were significant only to TNF- , when distributed PhA in tertiles. Adiponectin levels were higher among CRC patients. Although TNF-α;serum levels from CRC patients did not differ significantly to the control group, CRC patients with stage III or IV had higher levels compared to those with stage I and II tumors. Nutritional status, as determined by BMI, PhA, and PG-SGA, demonstrated that patients with a greatest nutritional deficit, had higher levels of adipocytokines; however, these differences were significant only for TNF-, when distributed PhA in tertiles.