Influence of diabetes surgery on gut hormones and incretins

The dramatic rise in the prevalence of obesity and type 2 diabetes mellitus (T2DM) has become a major global public health issue. There is increasing evidence that metabolic surgery is more effective than diet and exercise for diabetes remission and weight loss. Moreover, the rapid time course and d...

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Published inNutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral Vol. 28 Suppl 2; no. suppl 2; pp. 95 - 103
Main Authors Papamargaritis, D, Miras, A D, le Roux, Carel W
Format Journal Article
LanguageEnglish
Published Spain Grupo Arán 01.01.2013
Arán Ediciones, S. L
Subjects
Bariatric Surgery
Cirugía metabólica
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - surgery
Eje enteroinsular
Hormones - blood
Humans
Incretins - blood
Nutrition & Dietetics
Ácidos biliares
Cirugía metabólica
Metabolic surgery
Ácidos biliares
Eje enteroinsular
Enteroinsular axis
Bile acid
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Summary:The dramatic rise in the prevalence of obesity and type 2 diabetes mellitus (T2DM) has become a major global public health issue. There is increasing evidence that metabolic surgery is more effective than diet and exercise for diabetes remission and weight loss. Moreover, the rapid time course and disproportional degree of T2DM improvement after metabolic procedures compared with equivalent weight loss with conservative treatment, suggest surgery-specific, weight-independent effects on glucose homeostasis. Gut hormones has been proposed as one of the potential mechanisms for the weight-independent diabetes remission and long-term weight loss after these procedures. In this review we discuss the available current metabolic procedures and we review the current human data on changes in gut hormones after each metabolic procedure.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1699-5198
0212-1611
1699-5198
DOI:10.3305/nh.2013.28.sup2.6719