Development of nano-antimicrobial material based on bacterial cellulose, silver nanoparticles, and ClavaninA

Abstract This study presents a novel approach to obtaining nano-antimicrobial hybrid material by integrating electrospun nanofibers based on cellulosic biopolymer (BP) associated with antimicrobial agents, specifically silver nanoparticles (AgNPs) and Clavanin A (ClavA), an antimicrobial peptide obt...

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Published inPolímeros Vol. 34; no. 3
Main Authors Glícia Maria Oliveira, Alberto Galdino Silva-Junior, Octávio Luiz Franco, José Lamartine de Andrade Aguiar, Flávia Cristina Morone Pinto, Reginaldo Gonçalves de Lima-Neto, Maria Danielly Lima de Oliveira, César Augusto Souza de Andrade
Format Journal Article
LanguageEnglish
Published Associação Brasileira de Polímeros 01.01.2024
Subjects
antimicrobial peptide
Clavanin A
electrospinning
silver nanoparticles
sugarcane biopolymer
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Summary:Abstract This study presents a novel approach to obtaining nano-antimicrobial hybrid material by integrating electrospun nanofibers based on cellulosic biopolymer (BP) associated with antimicrobial agents, specifically silver nanoparticles (AgNPs) and Clavanin A (ClavA), an antimicrobial peptide obtained from the marine tunicate Styela clava. The electrospinning technique produced the blended polyvinyl alcohol:BP nanofibers. Chemical crosslinking was performed to ensure the stability of the nanofibers. The nanofibers had an average diameter of 568 nm for PVA nanofibers and 648 nm for PVA nanofibers functionalized with silver nanoparticles. The nanohybrid material demonstrates significant inhibition zones against Gram-positive (Bacillus subtilis, Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa, Klebsiella pneumoniae) bacteria. P. aeruginosa exhibits a substantial inhibition zone of 15 mm. Thus, the nanohybrid material was effective against this challenging pathogen. Combining electrospun nanofibers, bacterial cellulose hydrogel, and antimicrobial agents establishes a solution that could combat microbial threats in wound care.
ISSN:1678-5169
DOI:10.1590/0104-1428.20240029